Hypoxic cells have been linked to genetic instability and tumor progression. However, little is
known about the exact relationship between DNA repair and genetic instability in hypoxic …

Emerging evidence indicates that the tumor microenvironmental stress of hypoxia can
induce genetic instability in cancer cells. We and others have found that the expression …

Questions exist concerning the effects of acute versus chronic hypoxic conditions on DNA
replication and genomic stability that may influence tumorigenesis. Severe hypoxia causes …

The beneficial use of supplemental oxygen therapies to increase arterial blood oxygen
levels and reduce tissue hypoxia is offset by the knowledge that it injures and kills cells …

Areas of hypoxic tumour tissue are known to be resistant to treatment and are associated
with a poor clinical prognosis. There are several reasons why this might be, including the …

Hypoxia is a characteristic feature of solid tumors and occurs very early in neoplastic
development. Hypoxia transforms cell physiology in multiple ways, with profound changes in …

The tumor microenvironment is characterized by regions of fluctuating and chronic hypoxia,
low pH, and nutrient deprivation. It has been proposed that this unique tissue environment …

Areas of hypoxic tumour tissue are known to be resistant to treatment and are associated
with a poor clinical prognosis. There are several reasons why this might be, including the …

Hypoxia is a common feature of solid tumors and is associated with genetic instability and
tumor progression. It has been shown previously that alterations in the expression of DNA …

Cells deficient in repairing DNA double-strand breaks have an increased level of
spontaneous chromosomal aberrations. Modulating the level ofmolecular oxygen and its …