In clinical practice, cisplatin is the most commonly used chemotherapy drug to treat a range
of malignancies. Severe ROS-regulated nephrotoxicity, however, restricts its applicability …

The most frequent adverse effect of cisplatin-based chemotherapy is nephrotoxicity.
Oxidative stress has been implicated as an important mechanism in the pathogenesis of …

Cisplatin (CDDP) is a commonly prescribed chemotherapeutic agent; however, its
associated nephrotoxicity limits its clinical efficacy and sometimes requires discontinuation …

Although cisplatin is still one of the most effective chemotherapy agents for human cancers,
its clinical use is limited by serious side effects, especially nephrotoxicity. Oxidative stress is …

Oxidative stress damage of pancreatic β-cells is a key link in the pathogenesis of type 2
diabetes mellitus. A long-term increase of free fatty acids induces the increase of reactive …

Introduction The potential effects of selenium nanoparticles (SeNPs) administration on
arsenic exposure-mediated nephrotoxicity by alleviating fibrosis, inflammation, oxidative …

Aim Nephrotoxicity is the major limiting factor for the clinical use of vancomycin (VCM) for
treatment against multi-resistant Gram-positive bacteria. The present research aimed to …

Cisplatin-induced nephrotoxicity is highly correlated with reactive oxygen species (ROS)
overproduction, which greatly limits its clinical therapeutic effects. Therefore, identification of …

Abstract Background As Traditional Chinese Medicine (TCM) drugs, Huangqi and Danshen
are always applied in combination for spinal cord injury (SCI) treatment based on the …

Gentamycin (GM) is a widely used antibiotic for the treatment of Gram-negative bacterial
infections, but nephrotoxic effects limit its use. Selenium nanoparticles (SeNPs) have …