Persistent CB1 cannabinoid receptor activity limits neurotransmitter release at various
synapses throughout the brain. However, it is not fully understood how constitutively active …

Endocannabinoid-mediated retrograde synaptic signaling is a key regulator of GABA
release at synapses formed on the perisomatic region of pyramidal cells by basket cells that …

Endocannabinoid signaling couples activity-dependent rises in postsynaptic Ca2+ levels to
decreased presynaptic GABA release. Here, we present evidence from paired recording …

Endocannabinoids mediate retrograde signaling and modulate synaptic transmission in
various regions of the CNS. Depolarization-induced elevation of intracellular Ca2+ …

Endogenous cannabinoids (endocannabinoids) serve as retrograde messengers at
synapses in various regions of the brain. They are released from postsynaptic neurons and …

CB1 cannabinoid receptors (CB1) are located at axon terminals and effectively control
synaptic communication and thereby circuit operation widespread in the CNS. Although it is …

Endocannabinoid release from a single neuron has been shown to cause presynaptic
inhibition of transmitter release at many different sites. Here, we demonstrate that …

Endocannabinoids are retrograde messengers released by neurons to modulate the
strength of their synaptic inputs. Endocannabinoids are thought to mediate the suppression …

Endocannabinoids are released from postsynaptic neurons, activate presynaptic
cannabinoid receptors and cause various forms of short‐term and long‐term synaptic …

Postsynaptic Ca2+ signal influences synaptic transmission through multiple mechanisms.
Some of them involve retrograde messengers that are released from postsynaptic neurons …