Controlled cortical impact (CCI) is a commonly used and highly regarded model of brain
trauma that uses a pneumatically or electromagnetically controlled piston to induce …

The use of in vivo (ie, animal) models to study traumatic brain injury (TBI) is far from new;
indeed since the late 1800s many models of brain injury have been employed for this …

Controlled cortical impact (CCI), using a pneumatically driven impactor to produce traumatic
brain injury, has been characterized previously in both the ferret and in the rat. In the present …

Genetically modified mice represent useful tools for traumatic brain injury (TBI) research and
attractive preclinical models for the development of novel therapeutics. Experimental …

ABSTRACT A new experimental model of mechanical brain injury was produced in the
laboratory ferret (Mustela putorius furo) using a stroke-constrained pneumatic impactor …

Controlled cortical impact (CCI) is a mechanical model of traumatic brain injury (TBI) that
was developed nearly 30 years ago with the goal of creating a testing platform to determine …

Controlled cortical impact models produce brain injury by using a pneumatic impactor to
impact exposed brain. This study systematically examined the effects of varying magnitudes …

The controlled cortical impact (CCI) model is widely used in many laboratories to study
traumatic brain injury (TBI). Although external impact parameters during CCI tests could be …

Traumatic brain injury (TBI) is a major health concern worldwide. Laboratory studies utilizing
animal models of TBI are essential for addressing pathological mechanisms of brain injury …

Every year over a million Americans suffer a traumatic brain injury (TBI). Combined with the
incidence of TBIs worldwide, the physical, emotional, social, and economical effects are …