[HTML][HTML] Aminolevulinic acid-based tumor detection and therapy: molecular mechanisms and strategies for enhancement
X Yang, P Palasuberniam, D Kraus, B Chen - International journal of …, 2015 - mdpi.com
Aminolevulinic acid (ALA) is the first metabolite in the heme biosynthesis pathway in
humans. In addition to the end product heme, this pathway also produces other porphyrin …
humans. In addition to the end product heme, this pathway also produces other porphyrin …
Effects of silencing heme biosynthesis enzymes on 5‐aminolevulinic acid‐mediated protoporphyrin IX fluorescence and photodynamic therapy
X Yang, W Li, P Palasuberniam… - Photochemistry and …, 2015 - Wiley Online Library
Aminolevulinic acid (ALA)‐mediated protoporphyrin IX (Pp IX) production is being explored
for tumor fluorescence imaging and photodynamic therapy (PDT). As a prodrug, ALA is …
for tumor fluorescence imaging and photodynamic therapy (PDT). As a prodrug, ALA is …
[HTML][HTML] Enhancement of cancer-specific protoporphyrin IX fluorescence by targeting oncogenic Ras/MEK pathway
E Yoshioka, VS Chelakkot, M Licursi, SG Rutihinda… - Theranostics, 2018 - ncbi.nlm.nih.gov
Protoporphyrin IX (PpIX) is an endogenous fluorescent molecule that selectively
accumulates in cancer cells treated with the heme precursor 5-aminolevulinic acid (5-ALA) …
accumulates in cancer cells treated with the heme precursor 5-aminolevulinic acid (5-ALA) …
[HTML][HTML] 5-Aminolevulinic acid as a theranostic agent for tumor fluorescence imaging and photodynamic therapy
R Howley, S Chandratre, B Chen - Bioengineering, 2023 - mdpi.com
5-Aminolevulinic acid (ALA) is a naturally occurring amino acid synthesized in all nucleated
mammalian cells. As a porphyrin precursor, ALA is metabolized in the heme biosynthetic …
mammalian cells. As a porphyrin precursor, ALA is metabolized in the heme biosynthetic …
Protoporphyrin IX level correlates with number of mitochondria, but increase in production correlates with tumor cell size
SL Gibbs, B Chen, JA O'Hara… - Photochemistry and …, 2006 - Wiley Online Library
Protoporphyrin IX (PpIX) is produced in cells via the heme synthesis pathway, from the
substrate aminolevulinic acid (ALA), and can be used for tumor detection, monitoring or …
substrate aminolevulinic acid (ALA), and can be used for tumor detection, monitoring or …
[HTML][HTML] 5-Aminolevulinic acid-induced protoporphyrin IX fluorescence imaging for tumor detection: Recent advances and challenges
Y Harada, Y Murayama, T Takamatsu, E Otsuji… - International journal of …, 2022 - mdpi.com
5-Aminolevulinic acid (5-ALA) is a natural amino acid and a precursor of heme and
chlorophyll. Exogenously administered 5-ALA is metabolized into protoporphyrin IX (PpIX) …
chlorophyll. Exogenously administered 5-ALA is metabolized into protoporphyrin IX (PpIX) …
[HTML][HTML] The effect of iron ion on the specificity of photodynamic therapy with 5-aminolevulinic acid
M Hayashi, H Fukuhara, K Inoue, T Shuin, Y Hagiya… - PLoS …, 2015 - journals.plos.org
Recently, photodynamic therapy using 5-aminolevulinic acid (ALA-PDT) has been widely
used in cancer therapy. ALA administration results in tumor-selective accumulation of the …
used in cancer therapy. ALA administration results in tumor-selective accumulation of the …
Novel development of 5-aminolevurinic acid (ALA) in cancer diagnoses and therapy
M Ishizuka, F Abe, Y Sano, K Takahashi, K Inoue… - International …, 2011 - Elsevier
Early detection and intervention are needed for optimal outcomes in cancer therapy.
Improvements in diagnostic technology, including endoscopy, photodynamic diagnosis …
Improvements in diagnostic technology, including endoscopy, photodynamic diagnosis …
Direct Comparison of δ‐Aminolevulinic Acid and Methyl‐Aminolevulinate‐Derived Protoporphyrin IX Accumulations Potentiated by Desferrioxamine or the Novel …
A Pye, A Curnow - Photochemistry and photobiology, 2007 - Wiley Online Library
Aminolevulinic acid photodynamic therapy (ALA‐PDT) is a cancer therapy that combines the
selective accumulation of a photosensitizer in tumor tissue with visible light (and tissue …
selective accumulation of a photosensitizer in tumor tissue with visible light (and tissue …
5‐Aminolevulinic acid‐induced protoporphyrin IX levels in tissue of human malignant brain tumors
A Johansson, G Palte, O Schnell… - Photochemistry and …, 2010 - Wiley Online Library
Protoporphyrin IX (PpIX) produced from exogenous, orally administered 5‐aminolevulinic
acid (ALA) displays high tumor‐selective uptake and is being successfully employed for …
acid (ALA) displays high tumor‐selective uptake and is being successfully employed for …