Trypsin inhibitors: promising candidate satietogenic proteins as complementary treatment for obesity and metabolic disorders?

V Cristina Oliveira de Lima, G Piuvezam… - Journal of enzyme …, 2019 - Taylor & Francis
The increase in non-communicable chronic diseases has aroused interest in the research of
adjuvants to the classic forms of treatments. Obesity and metabolic syndrome are the main …

Key milestones in the diabetes research: A comprehensive update

A Gupta, T Behl, M Sachdeva - Obesity Medicine, 2020 - Elsevier
Diabetes has become a “lifestyle disease” and is growing epidemically on an alarming rate.
It has become a serious socio-economic burden on the developed and under developed …

Structural aspects of flavonoids as trypsin inhibitors

T Maliar, A Jedinák, J Kadrabová, E Šturdík - European journal of medicinal …, 2004 - Elsevier
In the search for new proteinase inhibitors we have focused on the screening and Computer
Assisted Drug Design (CADD) studies of polyphenolic compounds. In this paper we report …

Structural insights and molecular dynamics into the inhibitory mechanism of a Kunitz-type trypsin inhibitor from Tamarindus indica L

AF de Medeiros, BBP de Souza… - Journal of Enzyme …, 2021 - Taylor & Francis
Trypsin inhibitors from tamarind seed have been studied in vitro and in preclinical studies for
the treatment of obesity, its complications and associated comorbidities. It is still necessary …

Investigational therapies in the treatment of obesity

MC Mancini, A Halpern - Expert Opinion on Investigational Drugs, 2006 - Taylor & Francis
Obesity is a major public health concern and environmental factors are involved in its
development. The hypothalamus is a primary site for the integration of signals for the …

[HTML][HTML] Inhibitors of pancreatic lipase: state of the art and clinical perspectives

NA Lunagariya, NK Patel, SC Jagtap, KK Bhutani - EXCLI journal, 2014 - ncbi.nlm.nih.gov
Obesity is a disorder of lipid metabolism and continues to be a global problem, ranking fifth
for deaths worldwide. It also leads to diabetes, cardiovascular disorders, musculoskeletal …

[HTML][HTML] Novel molecules in diabetes mellitus, dyslipidemia and cardiovascular disease

CM Vesa, SG Bungau - International Journal of Molecular Sciences, 2023 - mdpi.com
The purpose of this Special Issue is to present the impact in clinical practice as well as in
medical research of novel molecules that have been introduced in the treatment of diabetes …

[HTML][HTML] Inhibitors of tryptase for the treatment of mast cell-mediated diseases

KD Rice, RD Tanaka, BA Katz… - Current …, 1998 - books.google.com
Human tryptase is a structurally unique and mast cell specific trypsin-like serine protease.
Recent biological and immunological investigations have implicated tryptase as a mediator …

[HTML][HTML] An integrated peptidomics and in silico approach to identify novel anti-diabetic peptides in Parmigiano-Reggiano cheese

S Martini, L Solieri, A Cattivelli, V Pizzamiglio… - Biology, 2021 - mdpi.com
Simple Summary Dietary habits and sedentary lifestyle are widely established to be the
major risk factors for the development of long-term chronic conditions, such as type-2 …

Pathophysiology of obesity: endocrine, inflammatory and neural regulators

K Bhattacharya, P Sengupta, S Dutta… - Research Journal of …, 2020 - indianjournals.com
Obesity is a “multi-metabolic and hormonal disease state” that primarily results from an
imbalanced physiological energy homeostasis. There is a wide range of factors that play …