DNA methylation represents a crucial mechanism of epigenetic regulation in hematologic
malignancies. The methylation process is controlled by specific DNA methyl transferases …

The rapid advances in high‐throughput sequencing technologies have made it more evident
that epigenetic modifications orchestrate a plethora of complex biological processes. During …

Genetic alterations, including DNA sequence and copy number alterations, have been
characterized in human cancers for over several decades. However, it is becoming …

Patterns of DNA methylation are established during embryonic development and faithfully
copied through somatic cell divisions. Based on current understanding of DNA methylation …

Introduction: There is evidence of the association of DNA methylation alterations with cancer
development and progression. Areas covered: This review will briefly discuss the basis of …

The pivotal role of aberrant promoter methylation in gene silencing and cancer development
has fueled the interest in DNA methyltransferase inhibitors as novel anticancer drugs …

Aberrant DNA methylation is a characteristic feature of cancers including blood
malignancies. Mutations in the DNA methylation regulators DNMT3A, TET1/2, and IDH1/2 …

Targeting DNA methylation for cancer therapy has had a rocky history. The first reports on
DNA methylation changes in cancer described global loss of methylation, which has been …

The term epigenetics refers to the heritable changes in gene expression that are not
associated with a change in the actual DNA sequence. Epigenetic dysregulation is linked to …

Targeting DNA hypermethylation, using nucleoside analogs, is an efficient approach to
reprogram cancer cell epigenome leading to reduced proliferation, increased differentiation …