2.1 Introduction lycosidases are responsible for the cleavage of glycosidic linkages and are
key in the turnover of glycans and glycoconjugates–a large and highly diverse class of …

The essential biological roles played by glycosidases, coupled to the diverse therapeutic
benefits of pharmacologically targeting these enzymes, provide considerable motivation for …

Glycosidases are a large, evolutionary conserved enzyme family that catalyze the hydrolysis
of glycosidic linkages of glycopolymers. These enzymes are involved in many (patho) …

Correction: Glycosylated cyclophellitol-derived activity-based probes and inhibitors for cellulases
Page 1 © 2021 The Author(s). Published by the Royal Society of Chemistry RSC Chem. Biol …

Cyclophellitol and cyclophellitol aziridine are potent and irreversible mechanism‐based
inhibitors of retaining β‐glucosidases. Alterations in the configuration of these compounds …

The natural product, cyclophellitol and its aziridine analogue are potent mechanism-based
retaining β-glucosidase inhibitors. In this paper we explore the inhibitory potency of a …

Cellulases and related β-1, 4-glucanases are essential components of lignocellulose-
degrading enzyme mixtures. The detection of β-1, 4-glucanase activity typically relies on …

Synthetic methodlogy is described, aiding in the synthetic preparation of putative inhibitors
of retaining and inverting glycosidases and glycosyl transferases. All constructs are …

Cyclitol epoxides and aziridines are potent and selective irreversible inhibitors of retaining
glycosidases. We have previously reported on our studies on the use of activity‐based …

Cyclophellitols are potent inhibitors of exo-and endoglycosidases. Efficient synthetic
methodologies are needed to fully capitalize on this intriguing class of mechanism-based …