Tumor recurrence is a paradoxical function of a machinery, whereby a small proportion of
the cancer cell population enters a resistant, dormant state, persists long-term in this …

Metastasis and relapse accounts for the great majority of cancer-related deaths. Most
metastatic lesions are micro metastases that have the capacity to remain in a non-dividing …

The development of metastasis is the major cause of death in cancer patients. In certain
instances, this occurs shortly after primary tumor detection and treatment, indicating these …

Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related
(ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression …

Autophagy is an intracellular lysosomal degradation process involved in multiple facets of
cancer biology. Various dimensions of autophagy are associated with tumor growth and …

Background The ability of a tumor to become dormant in response to suboptimal conditions
has recently been recognized as a key step in tumor progression. Tumor dormancy has …

Cancer progression involves a variety of pro-tumorigenic biological processes including cell
proliferation, migration, invasion, and survival. A cellular pathway implicated in these pro …

The tumor microenvironment (TME) is a complex environment where cancer cells reside and
interact with different types of cells, secreted factors, and the extracellular matrix …

Autophagy is a dynamic process involving the bulk degradation of cytoplasmic organelles
and proteins. Based on the function of “cellular recycling”, autophagy plays key roles in the …

Autophagy is a highly conserved metabolic process involved in the degradation of
intracellular components including proteins and organelles. Consequently, it plays a critical …