The histamine H4 receptor (H4R) activates Gαi-mediated signaling and recruits β-arrestin2
upon stimulation with histamine. β-Arrestins play a regulatory role in G protein-coupled …

It is widely assumed that G protein-coupled receptor kinase 2 (GRK2)-mediated specific
inhibition of G protein-coupled receptors (GPCRs) response involves GRK-mediated …

The H1 histamine receptor (H1HR) is a member of the G protein-coupled receptor
superfamily and regulates numerous cellular functions through its activation of the G q/11 …

To evaluate the role of G‐protein‐coupled receptor kinases (GRK) in the desensitization of
the histamine H2 receptor, the H2 receptor was transiently cotransfected with GRK2, 3, 5 or …

The Gi/o-coupled histamine H4 receptor is highly expressed in hemopoietic cells and is a
promising new target for the treatment of chronic inflammatory diseases. 1-[(5-Chloro-1 H …

The histamine H 3 receptor (H 3 R) is a neurotransmitter receptor that is primarily found in
the brain, where it controls the release and synthesis of histamine, as well as the release of …

The histamine H2 receptor (H2r) belongs to the heptahelical receptor family; upon agonist
binding, members of this family activate a G protein and the downstream effector adenylyl …

The human histamine H3 receptor (hH3R) is subject to extensive gene splicing that gives
rise to a large number of functional and nonfunctional isoforms. Despite the general …

G q protein-coupled histamine H 1 receptors play crucial roles in allergic and inflammatory
reactions, in which the phosphorylation of extracellular signal-regulated kinase (ERK) …

After the recent description of β-arrestin2 recruitment to the human histamine H4 receptor
(hH4R) in response to the well known H4R antagonist 1-[(5-chloro-1 H-indol-2-yl) carbonyl] …