[HTML][HTML] Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
SA Jones, J Scheller… - The Journal of clinical …, 2011 - Am Soc Clin Investig
The successful treatment of certain autoimmune conditions with the humanized anti–IL-6
receptor (IL-6R) antibody tocilizumab has emphasized the clinical importance of cytokines …
receptor (IL-6R) antibody tocilizumab has emphasized the clinical importance of cytokines …
[HTML][HTML] Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 …
C Garbers, W Thaiss, GW Jones, GH Waetzig… - Journal of Biological …, 2011 - ASBMB
IL-6 trans-signaling via the soluble IL-6 receptor (sIL-6R) plays a critical role in chronic
inflammation and cancer. Soluble gp130 (sgp130) specifically inhibits IL-6 trans-signaling …
inflammation and cancer. Soluble gp130 (sgp130) specifically inhibits IL-6 trans-signaling …
Targeting IL-6 in the treatment of inflammatory and autoimmune diseases
Background: IL-6, a glycoprotein composed of 212 amino acids in human, has a wide range
of biological activity, including regulation of immune response, support of hematopoiesis …
of biological activity, including regulation of immune response, support of hematopoiesis …
The biology and medical implications of interleukin-6
T Tanaka, T Kishimoto - Cancer immunology research, 2014 - AACR
Cytokines are soluble mediators, which aid cell-to-cell communication in immune
responses, and interleukin-6 (IL-6) is a prototypical cytokine featuring redundant and …
responses, and interleukin-6 (IL-6) is a prototypical cytokine featuring redundant and …
Interleukin-6: from basic biology to selective blockade of pro-inflammatory activities
J Scheller, C Garbers, S Rose-John - Seminars in immunology, 2014 - Elsevier
Cytokines receptors exist in membrane bound and soluble form. A soluble form of the
human IL-6R is generated by limited proteolysis and alternative splicing. The complex of IL …
human IL-6R is generated by limited proteolysis and alternative splicing. The complex of IL …
Targeting interleukin-6 in inflammatory autoimmune diseases and cancers
X Yao, J Huang, H Zhong, N Shen, R Faggioni… - Pharmacology & …, 2014 - Elsevier
Abstract Interleukin-6 (IL-6) is a pleiotropic cytokine with significant functions in the
regulation of the immune system. As a potent pro-inflammatory cytokine, IL-6 plays a pivotal …
regulation of the immune system. As a potent pro-inflammatory cytokine, IL-6 plays a pivotal …
[PDF][PDF] Pleiotropy and specificity: insights from the interleukin 6 family of cytokines
M Murakami, D Kamimura, T Hirano - Immunity, 2019 - cell.com
Since the molecular cloning of interleukin-6 (IL-6) in 1986, many other cytokines have been
found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL …
found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL …
Interleukin‐6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti‐gp130 monoclonal antibodies
J Wijdenes, PC Heinrich… - European journal of …, 1995 - Wiley Online Library
Abstract The cytokines interleukin (IL)‐6, IL‐11, ciliary neurotrophic factor (CNTF), leukemia
inhibitor factor (LIF), oncostatin M (OSM) and probably the recently cloned cytokine …
inhibitor factor (LIF), oncostatin M (OSM) and probably the recently cloned cytokine …
The soluble interleukin 6 receptor: advanced therapeutic options in inflammation
S Rose‐John - Clinical Pharmacology & Therapeutics, 2017 - Wiley Online Library
Interleukin (IL)‐6 binds to IL‐6R and the complex of IL‐6 and IL‐6R associates with the
receptor subunit gp130, which initiates signaling. gp130 is expressed on all cells. IL‐6R is …
receptor subunit gp130, which initiates signaling. gp130 is expressed on all cells. IL‐6R is …
Interleukin-6 and its receptor in autoimmunity
T Kishimoto - Journal of autoimmunity, 1992 - Elsevier
Interleukin-6 (IL-6) is a multifunctional cytokine which acts on a widevariety of cells,
regulating immune response, acute phase reaction and hematopoiesis. In accordance with …
regulating immune response, acute phase reaction and hematopoiesis. In accordance with …