Summary Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of
the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete …

Highlights•Alternative NLRP3 inflammasome activation comprises a distinct signaling
entity.•Genetic and phenotypic criteria distinguish alternative and classical NLRP3 …

Inflammasome activation culminates in activation of caspase‐1, which leads to the
maturation and subsequent release of cytokines of the interleukin 1 (IL‐1) family and results …

An inflammasome is a multiprotein complex that serves as a platform for caspase‐1
activation and caspase‐1‐dependent proteolytic maturation and secretion of interleukin‐1β …

Recognition of microbe‐associated molecular patterns or endogenous danger signals by a
subset of cytosolic PRRs results in the assembly of multiprotein signaling complexes, the so …

Inflammasome activation permits processing of interleukins (IL)-1β and 18 and elicits cell
death (pyroptosis). Whether these responses are independently licensed or are “hard-wired” …

The NLRP3 inflammasome is involved in caspase-1-dependent maturation of IL-1β in many
contexts. A two-signal model has emerged for IL-1β maturation, with LPS providing" signal I" …

We recently described the induction of noncanonical IL-1β processing via caspase-8
recruited to ripoptosome signaling platforms in myeloid leukocytes. Here, we demonstrate …

Highlights•IRF proteins regulate important components of inflammasome activation.•The
NLRP1b inflammasome is activated through 'functional degradation'.•NLRP6 senses …

Neutrophils play a pivotal role in the defense against bacterial, viral and fungal infections
and are important mediators in the acute inflammatory response. At the same time …