For a generation or more, the mass spectrometry that developed at the frontier of molecular
biology was worlds apart from isotope ratio mass spectrometry, a label-free approach done …

Biomolecules generally exist as mixtures of diverse isotopologues that differ in the number
and sites of rare-isotope substitutions. The exact proportion of isotopologues of a …

Stable isotopes of carbon, hydrogen, nitrogen, oxygen and sulfur are widespread in nature.
Nevertheless, their relative abundance is not the same everywhere. This is due to kinetic …

Isotope Ratio Mass Spectrometry (IRMS) is a specialized technique used to provide
information about the geographic, chemical, and biological origins of substances. The ability …

The isotope distribution, which reflects the number and probabilities of occurrence of
different isotopologues of a molecule, can be theoretically calculated. With the current …

Mass spectrometry is fundamental to measurements of isotope ratios for applications in
isotope geochemistry, geochronology, and cosmochemistry. Magnetic-sector mass …

Introduction Stable isotopic labeling experiments are powerful tools to study metabolic
pathways, to follow tracers and fluxes in biotic and abiotic transformations and to elucidate …

High precision isotope ratio mass spectrometry (IRMS) enables the detection of variability in
isotope abundance due to natural processes. IRMS instruments are highly specialized for …

Widely used isotope ratio mass spectrometers have limited capabilities to measure
metabolites, drugs, or small polyatomic ions without the loss of structural isotopic …

RATIONALE Soft ionization, high‐resolution mass spectrometry is widely used to
characterize large biological molecules, such as proteins. Deconvolution ('deisotoping') of …