DL‐3‐n‐butylphthalide promotes dendrite development in cortical neurons subjected to oxygen‐glucose deprivation/reperfusion

P Zhang, R Xu, Y Guo, J Qin, Y Dai… - Cell Biology …, 2018 - Wiley Online Library
The limited degree of functional recovery is closely associated with the condition of the
periinfarct cortex after ischemic stroke. The model of oxygen‐glucose deprivation in cultured …

Delayed combinatorial treatment with flavopiridol and minocycline provides longer term protection for neuronal soma but not dendrites following global ischemia

GO Iyirhiaro, TB Brust, J Rashidian… - Journal of …, 2008 - Wiley Online Library
We previously reported that delayed administration of the general cyclin‐dependent kinase
inhibitor flavopiridol following global ischemia provided transient neuroprotection and …

NMDA receptor mediated dendritic plasticity in cortical cultures after oxygen-glucose deprivation

Z Lei, Y Ruan, AN Yang, ZC Xu - Neuroscience letters, 2006 - Elsevier
Dendrites and spines undergo dynamic changes in physiological and pathological
conditions. Dendritic outgrowth has been observed in surviving neurons months after …

L-3-n-Butylphthalide reduces ischemic stroke injury and increases M2 microglial polarization

F Li, Q Ma, H Zhao, R Wang, Z Tao, Z Fan… - Metabolic brain …, 2018 - Springer
Overwhelming evidence suggests that microglia play an important role in ischemic injury
and they polarize into two different phenotypes with distinct functions after ischemic stroke …

DL-3-n-butylphthalide protects endothelial cells against oxidative/nitrosative stress, mitochondrial damage and subsequent cell death after oxygen glucose …

L Li, B Zhang, Y Tao, Y Wang, H Wei, J Zhao, R Huang… - Brain research, 2009 - Elsevier
dl-3-n-butylphthalide (NBP) has been used for stroke treatment in China for years. Recently,
we found that NBP can reduce the incidence of stroke and have protective action on …

Dl-3-n-butylphthalide exerts neuroprotective effects by modulating hypoxia-inducible factor 1-alpha ubiquitination to attenuate oxidative stress-induced apoptosis

S Li, J Zhao, Y Xi, J Ren, Y Zhu, Y Lu… - Neural Regeneration …, 2023 - journals.lww.com
Abstract Dl-3-n-butylphthalide is used to treat mild and moderate acute ischemic stroke.
However, the precise underlying mechanism requires further investigation. In this study, we …

[HTML][HTML] Targeting phosphodiesterase 4 as a potential therapeutic strategy for enhancing neuroplasticity following ischemic stroke

H Wang, U Gaur, J Xiao, B Xu, J Xu… - International journal of …, 2018 - ncbi.nlm.nih.gov
Sensorimotor recovery following ischemic stroke is highly related with structural modification
and functional reorganization of residual brain tissues. Manipulations, such as treatment …

The role of 7, 8-dihydroxyflavone in preventing dendrite degeneration in cortex after moderate traumatic brain injury

S Zhao, X Gao, W Dong, J Chen - Molecular neurobiology, 2016 - Springer
Our previous research showed that traumatic brain injury (TBI) induced by controlled cortical
impact (CCI) not only causes massive cell death, but also results in extensive dendrite …

Axonal outgrowth and dendritic plasticity in the cortical peri-infarct area after experimental stroke

Y Ueno, M Chopp, L Zhang, B Buller, Z Liu, NL Lehman… - Stroke, 2012 - Am Heart Assoc
Background and Purpose—Axonal remodeling is critical to brain repair after stroke. The
present study investigated axonal outgrowth after stroke and the signaling pathways …

EphrinB2-EphB2 signaling for dendrite protection after neuronal ischemia in vivo and oxygen-glucose deprivation in vitro

Z Yu, W Li, J Lan, K Hayakawa, X Ji… - Journal of Cerebral …, 2021 - journals.sagepub.com
In order to rescue neuronal function, neuroprotection should be required not only for the
neuron soma but also the dendrites. Here, we propose the hypothesis that ephrin-B2-EphB2 …