Human carboxylesterase 1A plays a predominant role in the hydrolytic activation of remdesivir in humans

F Zhang, HX Li, TT Zhang, Y Xiong, HN Wang… - Chemico-Biological …, 2022 - Elsevier
Remdesivir, an intravenous nucleotide prodrug, has been approved for treating COVID-19 in
hospitalized adults and pediatric patients. Upon administration, remdesivir can be readily …

In vitro evaluation of the impact of Covid-19 therapeutic agents on the hydrolysis of the antiviral prodrug remdesivir

Q Zhang, PW Melchert, JS Markowitz - Chemico-Biological Interactions, 2022 - Elsevier
Abstract Remdesivir (RDV, Veklury®) is an FDA-approved prodrug for the treatment of
hospitalized patients with COVID-19. Recent in vitro studies have indicated that human …

Remdesivir potently inhibits carboxylesterase‐2 through covalent modifications: Signifying strong drug‐drug interactions

Y Shen, W Eades, B Yan - Fundamental & clinical …, 2021 - Wiley Online Library
Remdesivir was recently approved to treat COVID‐19. While this antiviral agent delivers
clinical benefits, several safety concerns in many cases have been raised. This study reports …

Key metabolic enzymes involved in remdesivir activation in human lung cells

R Li, A Liclican, Y Xu, J Pitts, C Niu… - Antimicrobial agents …, 2021 - Am Soc Microbiol
ABSTRACT Remdesivir (RDV; GS-5734, Veklury), the first FDA-approved antiviral to treat
COVID-19, is a single-diastereomer monophosphoramidate prodrug of an adenosine …

Development and validation of a UHPLC-MS/MS method for quantification of the prodrug remdesivir and its metabolite GS-441524: a tool for clinical pharmacokinetics …

V Avataneo, A de Nicolo, J Cusato… - Journal of …, 2020 - academic.oup.com
Background Remdesivir has received significant attention for its potential application in the
treatment of COVID-19, caused by SARS-CoV-2. Remdesivir has already been tested for …

[HTML][HTML] Safety profile of the antiviral drug remdesivir: An update

Q Fan, B Zhang, J Ma, S Zhang - Biomedicine & Pharmacotherapy, 2020 - ncbi.nlm.nih.gov
The expanding epidemic of coronavirus disease 2019 (COVID-19), caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has posed a serious threat to the …

Identification and characterization of degradation products of Remdesivir using liquid chromatography/mass spectrometry

SB Dadinaboyina, NV Yerra, BM Adimoolam… - New Journal of …, 2021 - pubs.rsc.org
Remdesivir (RDV), a nucleoside analogue prodrug, is used to treat viral diseases including
COVID-19. The drug (RDV) was stressed under acidic, basic and neutral hydrolysis …

[PDF][PDF] Analytical method development and validation of Remdesivir in bulk and pharmaceutical dosage forms using reverse-phase-high performance liquid …

KM Raasi - BR Nahata Smriti Sansthan International Journal of …, 2021 - ijpscr.info
Background: Remdesivir has received significant attention for its potential application in the
treatment of COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS …

[HTML][HTML] Remdesivir for the treatment of Covid-19: the value of biochemical studies

M Götte - Current Opinion in Virology, 2021 - Elsevier
The nucleotide analogue prodrug remdesivir remains the only FDA-approved antiviral small
molecule for the treatment of infection with SARS-CoV-2. Biochemical studies revealed that …

ADME and pharmacokinetic properties of remdesivir: its drug interaction potential

S Deb, AA Reeves, R Hopefl, R Bejusca - Pharmaceuticals, 2021 - mdpi.com
On 11 March 2020, the World Health Organization (WHO) classified the Coronavirus
Disease 2019 (COVID-19) as a global pandemic, which tested healthcare systems …