Immune landscape of viral cancers: insights from single‐cell sequencing
Viral infections trigger a wide range of immune responses thought to drive tumorigenesis
and malignant progression. Dissecting virus‐induced changes in the tumor immune …
and malignant progression. Dissecting virus‐induced changes in the tumor immune …
Big data offers novel insights for oncolytic virus immunotherapy
SL Swift, DF Stojdl - Viruses, 2016 - mdpi.com
Large-scale assays, such as microarrays, next-generation sequencing and various “omics”
technologies, have explored multiple aspects of the immune response following virus …
technologies, have explored multiple aspects of the immune response following virus …
The viral expression and immune status in human cancers and insights into novel biomarkers of immunotherapy
S Chen, H Lai, J Zhao, B Chen, Y Li, Y Li, Q Li… - BMC cancer, 2021 - Springer
Background Viral infections are prevalent in human cancers and they have great diagnostic
and theranostic values in clinical practice. Recently, their potential of shaping the tumor …
and theranostic values in clinical practice. Recently, their potential of shaping the tumor …
Comprehensive characterization of tumor immune landscape following oncolytic virotherapy by single-cell RNA sequencing
An important mechanism of oncolytic virotherapy in ameliorating cancer immunotherapy is
by inducing significant changes in the immune landscape in the tumor microenvironment …
by inducing significant changes in the immune landscape in the tumor microenvironment …
High-throughput screening to enhance oncolytic virus immunotherapy
KJ Allan, DF Stojdl, SL Swift - Oncolytic virotherapy, 2016 - Taylor & Francis
High-throughput screens can rapidly scan and capture large amounts of information across
multiple biological parameters. Although many screens have been designed to uncover …
multiple biological parameters. Although many screens have been designed to uncover …
Insights gained from single-cell analysis of immune cells in the tumor microenvironment
Understanding tumor immune microenvironments is critical for identifying immune modifiers
of cancer progression and developing cancer immunotherapies. Recent applications of …
of cancer progression and developing cancer immunotherapies. Recent applications of …
1512 Single-cell resolution spatial transcriptomics detection of pathogens followed by studying the immune milieu: using virus-associated cancers from different …
Y Wu, F Wee, LY Chong, ZW Neo, J Lim, Y Xue… - 2023 - jitc.bmj.com
Background Tumor Immuno-MicroEnvironment (TIME) is characterized by a heterogeneous
interplay of cellular and molecular components. For the TIME of cancers caused by virus …
interplay of cellular and molecular components. For the TIME of cancers caused by virus …
Exploring oncolytic virus-mediated changes in immune microenvironment and immune cells in solid tumors
H Zhang - Frontiers in Immunology, 2023 - frontiersin.org
Oncolytic virus (OV) therapy is a promising cancer treatment strategy, which selectively
replicates in and destroys tumor cells rather than normal cells, thereby effectively releasing …
replicates in and destroys tumor cells rather than normal cells, thereby effectively releasing …
Unravelling immune microenvironment features underlying tumor progression in the single-cell era
Q Du, Q An, J Zhang, C Liu, Q Hu - Cancer Cell International, 2024 - Springer
The relationship between the immune cell and tumor occurrence and progression remains
unclear. Profiling alterations in the tumor immune microenvironment (TIME) at high …
unclear. Profiling alterations in the tumor immune microenvironment (TIME) at high …
The current landscape of single-cell transcriptomics for cancer immunotherapy
Immunotherapies such as immune checkpoint blockade and adoptive cell transfer have
revolutionized cancer treatment, but further progress is hindered by our limited …
revolutionized cancer treatment, but further progress is hindered by our limited …