Infection with the protozoan parasite Cryptosporidium parvum (CP) causes
cryptosporidiosis, a widespread diarrhoeal disease. Impaired intestinal epithelial barrier …

Intestinal epithelial cells form a single layer separating the intestinal lumen containing
nutriments and microbiota from the underlying sterile tissue and therefore play a key role in …

Cryptosporidium is a leading cause of diarrhea and death in young children and untreated
AIDS patients and causes waterborne outbreaks. Pathogenic mechanisms underlying …

Autophagy, a process of degradation and recycling of macromolecules and organelles to
maintain cellular homeostasis, has also been shown to help eliminate invading pathogens …

Exposure to oocysts of the protozoan Cryptosporidium parvum causes intestinal epithelial
cell dysfunction in vivo and in vitro, but effective means by which mucosal injury might be …

Cryptosporidium parvum infects intestinal epithelial cells and does not invade deeper layers
of the intestinal mucosa. Nonetheless, an inflammatory cell infiltrate that consists of …

Cryptosporidium parvum is an obligate intracellular protozoan capable of causing life-
threatening diarrhoeal disease in immunocompromised individuals. Efforts to develop novel …

Cryptosporidium parvum can be regarded as a minimally invasive mucosal pathogen, since
it invades surface epithelial cells that line the intestinal tract but does not invade deeper …

Cryptosporidium, a ubiquitous coccidian protozoan parasite that infects the gastrointestinal
epithelium and other mucosal surfaces, is an important opportunistic pathogen for …

The apicomplexan parasite Cryptosporidium causes significant diarrheal disease
worldwide. Effective anticryptosporidial agents are lacking, in part because the molecular …