Nature is considered a prolific source of diverse biologically active chemotypes. While most
reviews have focused on the characteristics of the chemical backbones of natural products …

Natural products (NPs) have been used as traditional medicines since antiquity. With more
than 1060 estimated compounds with molecular weights less than 500 Da representing …

Abstract “If only they had chosen to develop natural product drugs in a sustainable manner
at the turn of the century”. In 2050, when the Earth has a population of at least 9 billion, will …

Context: In recent decades, natural products have undisputedly played a leading role in the
development of novel medicines. Yet, trends in the pharmaceutical industry at the level of …

This contribution is a completely updated and expanded version of the four prior analogous
reviews that were published in this journal in 1997, 2003, 2007, and 2012. In the case of all …

Covering: up to 2016 Marine and terrestrial organisms yield a remarkable chemical diversity
and are important sources for discovery of new chemical products. In order to maximize the …

This review is an updated and expanded version of the three prior reviews that were
published in this journal in 1997, 2003, and 2007. In the case of all approved therapeutic …

Natural products (NPs) have consistently played a pivotal role in pharmaceutical research,
exerting profound impacts on the treatment of human diseases. A significant proportion of …

Natural Products have been the most significant source of drugs and drug leads in history.
Their dominant role in cancer chemotherapeutics is clear with about 74% of anticancer …

Nature stands as an inexhaustible source of novel chemotypes and pharmacophores, and
has been a source of medicinal agents for thousands of years, and an impressive number of …