The induction of autophagy, the catabolic pathway by which damaged or unnecessary
cellular components are subjected to lysosome-mediated degradation and recycling, is …

Autophagy is a self-degradative process responsible for the clearance of damaged or
unnecessary cellular components. We have previously found that persistence of …

ABSTRACT COL6 (collagen type VI)-related myopathies (COL6-RM) are a distinct group of
inherited muscle disorders caused by mutations of COL6 genes and characterized by early …

Autophagy is a catabolic process that provides the degradation of altered/damaged
organelles through the fusion between autophagosomes and lysosomes. Proper regulation …

Autophagy is a cellular degradation and recycling process by which cytoplasmic
components, including macromolecules and organelles, are sequestered into specialized …

Skeletal muscle fibers of collagen VI null (Col6a1−/−) mice show signs of degeneration due
to a block in autophagy, leading to the accumulation of damaged mitochondria and …

Collagen VI is an extracellular matrix protein forming a microfibrillar network in the
endomysium of skeletal muscles. In humans, mutations in any of the three genes coding for …

Autophagy is crucial in the turnover of cell components, and clearance of damaged
organelles by the autophagic-lysosomal pathway is essential for tissue homeostasis …

Collagen VI (ColVI) is an abundant and distinctive extracellular matrix protein secreted by
fibroblasts in different tissues. Human diseases linked to mutations on ColVI genes are …

Mutations of genes encoding for collagen VI cause various muscle diseases in humans,
including Bethlem myopathy and Ullrich congenital muscular dystrophy. Collagen VI null …