As an evolutionarily conserved intracellular degradation pathway, autophagy is essential to
cellular homeostasis. Several studies have demonstrated that autophagy showed an …

Autophagy is a process of cell self-renewal that is dependent on the degradation of the
cytoplasmic proteins or organelles of lysosomes. Many diseases, such as metabolic …

Autophagy is a highly conserved catabolic process involving autolysosomal degradation of
cellular components, including protein aggregates, damaged organelles (such as …

Background Autophagy is a basic cellular homeostatic process important to cell fate
decisions under conditions of stress. Dysregulation of autophagy impacts numerous human …

Idiopathic pulmonary fibrosis (IPF) is an interstitial pulmonary disease with an extremely
poor prognosis. Autophagy is a fundamental intracellular process involved in maintaining …

Autophagy is a highly conserved homeostatic pathway by which cells transport damaged
proteins and organelles to lysosomes for degradation. Dysregulation of autophagy …

Silicosis is an urgent public health problem in many countries. Alveolar macrophage (AM)
plays an important role in silicosis progression. Autophagy is a balanced mechanism for …

(Macro) autophagy provides a membrane-dependent mechanism for the sequestration,
transport, and lysosomal turnover of subcellular components, including proteins and …

Macroautophagy (hereafter referred to as autophagy) is an evolutionally conserved
intracellular process to maintain cellular homeostasis by facilitating the turnover of protein …

The molecular and cellular mechanisms underlying the pathogenesis of chronic obstructive
pulmonary disease (COPD) remain incompletely understood. We have investigated the …