BMSC-derived exosomes promote tendon-bone healing after anterior cruciate ligament reconstruction by regulating M1/M2 macrophage polarization in rats

Z Li, Q Li, K Tong, J Zhu, H Wang, B Chen… - Stem Cell Research & …, 2022 - Springer
Background Recent studies have shown that bone marrow stromal cell-derived exosomes
(BMSC-Exos) can be used for tissue repair. However, whether the BMSC-Exos can promote …

Bone marrow mesenchymal stem cell-derived exosomes promote rotator cuff tendon-bone healing by promoting angiogenesis and regulating M1 macrophages in rats

Y Huang, B He, L Wang, B Yuan, H Shu… - Stem Cell Research & …, 2020 - Springer
Abstract Background Rotator cuff tears (RCTs) often require reconstructive surgery. Tendon-
bone healing is critical for the outcome of rotator cuff reconstruction, but the process of …

[HTML][HTML] Exosomes derived from bone marrow stromal cells (BMSCs) enhance tendon-bone healing by regulating macrophage polarization

Y Shi, X Kang, Y Wang, X Bian, G He… - … medical journal of …, 2020 - ncbi.nlm.nih.gov
Background Inflammation after tendon-bone junction injury results in the formation of
excessive scar tissue and poor biomechanical properties. Recent research has shown that …

[HTML][HTML] Exosomes derived from magnetically actuated bone mesenchymal stem cells promote tendon-bone healing through the miR-21-5p/SMAD7 pathway

XD Wu, L Kang, J Tian, Y Wu, Y Huang, J Liu… - Materials Today Bio, 2022 - Elsevier
Graft healing after anterior cruciate ligament reconstruction (ACLR) involves slow biological
processes, and various types of biological modulations have been explored to promote …

Bone marrow stromal cell-derived exosomes promote muscle healing following contusion through macrophage polarization

Z Luo, J Lin, Y Sun, C Wang, J Chen - Stem Cells and Development, 2021 - liebertpub.com
Skeletal muscle contusion is among the most common injuries in traumatology and clinics of
sports medicine. The injured muscle is vulnerable to re-injury owing to fibrosis formation …

Bone marrow mesenchymal stem cell-derived exosomes promote tendon regeneration by facilitating the proliferation and migration of endogenous tendon stem …

H Yu, J Cheng, W Shi, B Ren, F Zhao, Y Shi, P Yang… - Acta biomaterialia, 2020 - Elsevier
Mesenchymal stem cells (MSCs)-derived exosomes are being increasingly focused as the
new biological pro-regenerative therapeutic agents for various types of tissue injury. Here …

Tendon stem cell-derived exosomes regulate inflammation and promote the high-quality healing of injured tendon

M Zhang, H Liu, Q Cui, P Han, S Yang, M Shi… - Stem cell research & …, 2020 - Springer
Abstract Background Tendon stem cells (TSCs) have been reported to hold promises for
tendon repair and regeneration. However, less is known about the effects of exosomes …

Exosomes from bone marrow mesenchymal stem cells enhance fracture healing through the promotion of osteogenesis and angiogenesis in a rat model of nonunion

L Zhang, G Jiao, S Ren, X Zhang, C Li, W Wu… - Stem cell research & …, 2020 - Springer
Background As important players in cell-to-cell communication, exosomes (exo) are
believed to play a similar role in promoting fracture healing. This study investigated whether …

Therapeutic effects of bone marrow mesenchymal stem cells‐derived exosomes on osteoarthritis

Y Jin, M Xu, H Zhu, C Dong, J Ji, Y Liu… - Journal of cellular …, 2021 - Wiley Online Library
Mesenchymal stem cells (MSCs) have shown chondroprotective effects in clinical models of
osteoarthritis (OA). However, effects of MSC‐derived exosomes on OA remain unclear. The …

Therapeutic potential and mechanisms of mesenchymal stem cell-derived exosomes as bioactive materials in tendon–bone healing

J Zou, W Yang, W Cui, C Li, C Ma, X Ji, J Hong… - Journal of …, 2023 - Springer
Tendon–bone insertion (TBI) injuries, such as anterior cruciate ligament injury and rotator
cuff injury, are the most common soft tissue injuries. In most situations, surgical …