Mechanistic studies are presented of a novel class of aminophosphine platinum (II)
complexes as potential anticancer agents. These new agents, which have demonstrated …

The presence of cis-configured exchangeable ligands has long been considered a
prerequisite for antitumor activity of platinum complexes, but over the past few years, several …

Chloroammine and similar complexes of platinum (II) having the ammine ligands in the cis
configuration are effective antitumor agents but the corresponding trans isomers are not …

Chemical and biological studies are presented for a new series of platinum (II) antitumor
agents that violate the classical structure-activity relationships established for platinum …

The continued use of platinum-based chemotherapeutic drugs in the clinic mandates the
need for further investigation of the biological activity of structural analogues of the clinically …

Two series of organoamidoplatinum (II) complexes were synthesized [Class 1, Pt (NRCH 2)
2 L 2 and Class 2, Pt (NRCH 2 CH 2 NR 2′) L (X)] and their antitumour activity examined by …

Thioether binding mediates monofunctional platinum antitumor reagents to trans
configuration in DNA interactions - Chemical Communications (RSC Publishing) DOI:10.1039/C0CC01408G …

Cisplatin, a simple inorganic compound, has been one of the leading antitumor drugs for
near 30 years. However, cisplatin has several drawbacks such as toxicity and drug …

DNA is believed to be the molecular target for the cytotoxic activities of platinum (Pt)
anticancer drugs. We report here a class of platinum (II)-and platinum (IV)-pyrophosphato …

A series of platinum compounds with an analogue structure to cisplatin have been
synthesized and their biological activity against HL-60 cancer cell line has been studied …