WNT signalling comprises a diverse spectrum of receptor-mediated pathways activated by a
large family of WNT ligands and influencing fundamental biological processes. WNT …

Wnt signaling pathways play a key role in cardiac development, angiogenesis, and cardiac
hypertrophy; emerging evidence suggests that they are also involved in the pathophysiology …

Components of the Wnt signaling cascade represent novel targets for pharmacological
intervention in cardiometabolic disease. Conversely, strategies targeting the Wnt signaling …

WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

Growth factor signaling is required for cellular differentiation, tissue morphogenesis, and
tissue homeostasis. Misregulation of intracellular signal transduction can lead to …

Emerging evidence indicates that Wnt signaling regulates crucial aspects of cardiovascular
biology (including cardiac morphogenesis, and the self-renewal and differentiation of …

Atherosclerosis, a pathology affecting large and medium-sized arteries, is the major cause of
cardiovascular morbidity/mortality in industrialized countries. During atherosclerosis, cells …

Proteins from the Wnt family have been implicated in cell–cell communication in a wide
variety of developmental and physiological processes. Wnt signaling is required for different …

On pathological stress, the heart reactivates several signaling pathways that traditionally
were thought to be operational only in the developing heart. One of these pathways is the …

Early stages of vascular development include endothelial cell differentiation in a network of
arteries, veins, and lymphatics. Subsequently, to respond to the specific needs of the organs …