Normal aging leads to endothelial dysfunction and arterial stiffening implicated in cognitive
decline. Cerebral blood flow also declines with aging. Elevated blood flow during exercise …

Advanced age is the major risk factor for dementia including Alzheimer's disease. The
clinical effects of recently developed anti-amyloid therapy for Alzheimer's disease were …

Exercise is associated with higher cognitive function and is a promising intervention to
reduce the risk of dementia. With advancing age, there are changes in the vasculature that …

Reduced cerebrovascular reactivity to a vasoactive stimulus is associated with age-related
diseases such as stroke and cognitive decline. Habitual exercise is protective against …

Background: Midlife vascular disease risk is a strong risk factor for late-life dementia. Central
arterial stiffness, a hallmark of vascular aging, is associated with accelerated brain aging …

Arterial aging may contribute to reduction in brain perfusion in older adults. We assessed the
hypothesis that aerobic exercise training reduces arterial stiffness and improves brain …

Background. Stiffness of the central arteries in aging may contribute to cerebral
microvascular disease independent of hypertension and other vascular risk factors. Few …

Background: Evidence of the benefits of aerobic exercise training (AET) on brain structure,
function, and perfusion in older adults is inconclusive. Methods: We conducted two …

The rapid hemodynamic changes induced by the initiation of dynamic exercise robustly
challenge the regulatory processes which ensure that cerebral perfusion is appropriately …

Background Age‐related impairments in cerebrovascular function likely contribute to
cognitive decline with aging. In particular, cerebral artery stiffening with aging leads to …