[HTML][HTML] A review of using mathematical modeling to improve our understanding of bacteriophage, bacteria, and eukaryotic interactions

KM Styles, AT Brown, AP Sagona - Frontiers in Microbiology, 2021 - frontiersin.org
Phage therapy, the therapeutic usage of viruses to treat bacterial infections, has many
theoretical benefits in the 'post antibiotic era.'Nevertheless, there are currently no approved …

Modeling bacteria–phage interactions and its implications for phage therapy

S Sinha, RK Grewal, S Roy - Advances in applied microbiology, 2018 - Elsevier
Bacteriophages are more abundant than any other organism on our planet. The interaction
of bacteriophages and bacteria and their coevolution is well known. In this chapter, we …

Computational approaches to predict bacteriophage–host relationships

RA Edwards, K McNair, K Faust, J Raes… - FEMS microbiology …, 2016 - academic.oup.com
Metagenomics has changed the face of virus discovery by enabling the accurate
identification of viral genome sequences without requiring isolation of the viruses. As a …

Quantitative Models of In Vitro Bacteriophage–Host Dynamics and Their Application to Phage Therapy

BJ Cairns, AR Timms, VAA Jansen, IF Connerton… - PLoS …, 2009 - journals.plos.org
Phage therapy is the use of bacteriophages as antimicrobial agents for the control of
pathogenic and other problem bacteria. It has previously been argued that successful …

Population and evolutionary dynamics of phage therapy

BR Levin, JJ Bull - Nature Reviews Microbiology, 2004 - nature.com
Following a sixty-year hiatus in western medicine, bacteriophages (phages) are again being
advocated for treating and preventing bacterial infections. Are attempts to use phages for …

[PDF][PDF] Quantitative models of phage-antibiotic combination therapy. mSystems 5: e00756-19

RA Rodriguez-Gonzalez, CY Leung, BK Chan… - 2020 - researchgate.net
The spread of multidrug-resistant (MDR) bacteria is a global public health crisis.
Bacteriophage therapy (or “phage therapy”) constitutes a potential alternative approach to …

[PDF][PDF] Combination of in vivo phage therapy data with in silico model highlights key parameters for pneumonia treatment efficacy

R Delattre, J Seurat, F Haddad, TT Nguyen… - Cell Reports, 2022 - cell.com
The clinical (re) development of bacteriophage (phage) therapy to treat antibiotic-resistant
infections faces the challenge of understanding the dynamics of phage-bacteria interactions …

Systematic analysis of putative phage-phage interactions on minimum-sized phage cocktails

F Molina, M Menor-Flores, L Fernández… - Scientific Reports, 2022 - nature.com
The application of bacteriophages as antibacterial agents has many benefits in the “post-
antibiotic age”. To increase the number of successfully targeted bacterial strains, phage …

Promises and pitfalls of in vivo evolution to improve phage therapy

JJ Bull, BR Levin, IJ Molineux - Viruses, 2019 - mdpi.com
Phage therapy is the use of bacterial viruses (phages) to treat bacterial infections, a medical
intervention long abandoned in the West but now experiencing a revival. Currently …

Black box of phage–bacterium interactions: Exploring alternative phage infection strategies

S Mäntynen, E Laanto, HM Oksanen… - Open …, 2021 - royalsocietypublishing.org
The canonical lytic–lysogenic binary has been challenged in recent years, as more
evidence has emerged on alternative bacteriophage infection strategies. These infection …