Structure and organization of mitochondrial respiratory complexes: a new understanding of an old subject

G Lenaz, ML Genova - Antioxidants & redox signaling, 2010 - liebertpub.com
The enzymatic complexes of the mitochondrial respiratory chain have been extensively
investigated in their structural and functional properties. A clear distinction is possible today …

Structural and functional organization of the mitochondrial respiratory chain: a dynamic super-assembly

G Lenaz, ML Genova - The international journal of biochemistry & cell …, 2009 - Elsevier
The structural organization of the mitochondrial oxidative phosphorylation (OXPHOS)
system has received large attention in the past and most investigations led to the conclusion …

Mitochondrial respiratory supercomplex association limits production of reactive oxygen species from complex I

E Maranzana, G Barbero, AI Falasca… - Antioxidants & redox …, 2013 - liebertpub.com
Aims: The mitochondrial respiratory chain is recognized today to be arranged in
supramolecular assemblies (supercomplexes). Besides conferring a kinetic advantage …

Supramolecular organisation of the mitochondrial respiratory chain: a new challenge for the mechanism and control of oxidative phosphorylation

G Lenaz, ML Genova - … : nuclear-encoded genes, enzyme regulation, and …, 2012 - Springer
Recent experimental evidence has replaced the random diffusion model of electron transfer
with a model of supramolecular organisation based on specific interactions between …

[HTML][HTML] Functional role of mitochondrial respiratory supercomplexes

ML Genova, G Lenaz - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2014 - Elsevier
Recent experimental evidence has replaced the random diffusion model of electron transfer
with a model of supramolecular organisation based upon specific interactions between …

The mitochondrial respiratory chain is partially organized in a supercomplex assembly: kinetic evidence using flux control analysis

C Bianchi, ML Genova, GP Castelli, G Lenaz - Journal of Biological …, 2004 - ASBMB
The model of the respiratory chain in which the enzyme complexes are independently
embedded in the lipid bilayer of the inner mitochondrial membrane and connected by …

The assembly, regulation and function of the mitochondrial respiratory chain

I Vercellino, LA Sazanov - Nature Reviews Molecular Cell Biology, 2022 - nature.com
The mitochondrial oxidative phosphorylation system is central to cellular metabolism. It
comprises five enzymatic complexes and two mobile electron carriers that work in a …

[HTML][HTML] Mitochondrial respiratory chain super-complex I–III in physiology and pathology

G Lenaz, A Baracca, G Barbero, C Bergamini… - … et Biophysica Acta (BBA …, 2010 - Elsevier
Recent investigations by native gel electrophoresis showed the existence of supramolecular
associations of the respiratory complexes, confirmed by electron microscopy analysis and …

[HTML][HTML] The function of the respiratory supercomplexes: the plasticity model

R Acin-Perez, JA Enriquez - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
Mitochondria are important organelles not only as efficient ATP generators but also in
controlling and regulating many cellular processes. Mitochondria are dynamic …

Respiratory supercomplexes: structure, function and assembly

R Vartak, CAM Porras, Y Bai - Protein & cell, 2013 - academic.oup.com
The mitochondrial respiratory chain consists of 5 enzyme complexes that are responsible for
ATP generation. The paradigm of the electron transport chain as discrete enzymes diffused …