There is a brief introductory summary of purinergic signaling involving ATP storage, release,
and ectoenzymatic breakdown, and the current classification of receptor subtypes for …

There is a brief summary of the early background literature about purinergic signalling and
its involvement in pain, of ATP storage, release and ectoenzymatic breakdown and of the …

There is a brief summary of the background literature about purinergic signalling. The review
then considers purinergic mechanosensory transduction involved in visceral, cutaneous and …

A growing body of evidence indicates that extracellular nucleotides play important roles in
the regulation of neuronal and glial functions in the nervous system through P2 …

Receptor subtypes for purines have been identified in a variety of tissues, increasing interest
in the roles of purine-mediated signalling in pathophysiological processes. Growing …

Some areas of current interest in the rapidly expanding purinergic signalling field that are
controversial or are unresolved are highlighted in this review. These include the …

Following hints in the early literature about adenosine 5′-triphosphate (ATP) injections
producing pain, an ion-channel nucleotide receptor was cloned in 1995, P2X3 subtype …

We have learned various data on the role of purinoceptors (P2X4, P2X7, P2Y6 and P2Y12)
expressed in spinal microglia and several factors that presumably activate microglia in …

The concept of a purinergic signalling system, using purine nucleotides and nucleosides as
extracellular messengers, was first proposed over 30 years ago. After a brief historical …

Purines, such as adenosine and ATP, are endogenous ligands involved in modulating pain
transmission and pain hypersensitivity by acting on P1 and P2 purinoceptors, respectively …