Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper
CV Sørensen, J Fernández, AC Adams… - Nature …, 2024 - nature.com
Improved therapies are needed against snakebite envenoming, which kills and permanently
disables thousands of people each year. Recently developed neutralizing monoclonal …
disables thousands of people each year. Recently developed neutralizing monoclonal …
Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins
IS Khalek, RR Senji Laxme, YTK Nguyen… - Science Translational …, 2024 - science.org
Snakebite envenoming is a major global public health concern for which improved therapies
are urgently needed. The antigenic diversity present in snake venom toxins from various …
are urgently needed. The antigenic diversity present in snake venom toxins from various …
Exploring the utility of recombinant snake venom serine protease toxins as immunogens for generating experimental snakebite antivenoms
N Alomran, P Blundell, J Alsolaiss, E Crittenden… - Toxins, 2022 - mdpi.com
Snakebite is a neglected tropical disease that causes high rates of global mortality and
morbidity. Although snakebite can cause a variety of pathologies in victims, haemotoxic …
morbidity. Although snakebite can cause a variety of pathologies in victims, haemotoxic …
Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes
Snakebite envenoming continues to claim many lives across the globe, necessitating the
development of improved therapies. To this end, broadly-neutralizing human monoclonal …
development of improved therapies. To this end, broadly-neutralizing human monoclonal …
An in vitro methodology for discovering broadly-neutralizing monoclonal antibodies
Broadly-neutralizing monoclonal antibodies are of high therapeutic utility against infectious
diseases caused by bacteria and viruses, as well as different types of intoxications …
diseases caused by bacteria and viruses, as well as different types of intoxications …
Toxin neutralization using alternative binding proteins
TP Jenkins, T Fryer, RI Dehli, JA Jürgensen… - Toxins, 2019 - mdpi.com
Animal toxins present a major threat to human health worldwide, predominantly through
snakebite envenomings, which are responsible for over 100,000 deaths each year. To date …
snakebite envenomings, which are responsible for over 100,000 deaths each year. To date …
Development of Nanobodies Against Hemorrhagic and Myotoxic Components of Bothrops atrox Snake Venom
H Bailon Calderon, VO Yaniro Coronel… - Frontiers in …, 2020 - frontiersin.org
Snake envenoming is a globally neglected public health problem. Antivenoms produced
using animal hyperimmune plasma remain the standard therapy for snakebites. Although …
using animal hyperimmune plasma remain the standard therapy for snakebites. Although …
Antibodies as snakebite antivenoms: past and future
W Dias da Silva, SA De Andrade, ÂAA Megale… - Toxins, 2022 - mdpi.com
Snakebite envenomation is considered a neglected tropical disease, affecting tens of
thousands of people each year. The recommended treatment is the use of antivenom, which …
thousands of people each year. The recommended treatment is the use of antivenom, which …
Inhibition of the Myotoxicity Induced by Bothrops jararacussu Venom and Isolated Phospholipases A2 by Specific Camelid Single-Domain Antibody Fragments
NDR Prado, SS Pereira, MP da Silva, MSS Morais… - PLoS …, 2016 - journals.plos.org
Antivenoms, produced using animal hyperimmune plasma, remains the standard therapy for
snakebites. Although effective against systemic damages, conventional antivenoms have …
snakebites. Although effective against systemic damages, conventional antivenoms have …
[图书][B] Recombinant antivenoms
With an annual 5 million cases, 150,000 deaths, and about 400,000 amputations, snakebite
envenoming is an ever-present threat in many parts of the rural tropical world. Parental …
envenoming is an ever-present threat in many parts of the rural tropical world. Parental …