Negative in vivo results despite promising in vitro data with a coated compliant electrospun polyurethane vascular graft

W Fortin, M Bouchet, E Therasse, M Maire… - Journal of Surgical …, 2022 - Elsevier
Introduction There is a growing need for small-diameter (< 6 mm) off-the-shelf synthetic
vascular conduits for different surgical bypass procedures, with actual synthetic conduits …

Electrospun polyurethane-based vascular grafts: Physicochemical properties and functioning in vivo

AA Gostev, VS Chernonosova, IS Murashov… - Biomedical …, 2019 - iopscience.iop.org
General physicochemical properties of the vascular grafts (VGs) produced from the solutions
of Tecoflex (Tec) with gelatin (GL) and bivalirudin (BV) by electrospinning are studied. The …

[HTML][HTML] In vivo stability of polyurethane-based electrospun vascular grafts in terms of chemistry and mechanics

AA Gostev, IK Shundrina, VI Pastukhov, AV Shutov… - Polymers, 2020 - mdpi.com
The biostability of the polyurethanes Tecoflex EG-80A and Pellethane 2363-80A, used as
basic polymers of the vascular grafts (VGs) produced by electrospinning, as well as the …

End-point immobilization of heparin on plasma-treated surface of electrospun polycarbonate-urethane vascular graft

X Qiu, BLP Lee, X Ning, N Murthy, N Dong, S Li - Acta biomaterialia, 2017 - Elsevier
Small-diameter synthetic vascular grafts have high failure rate due to primarily surface
thrombogenicity, and effective surface chemical modification is critical to maintain the …

Electrospun vascular grafts with improved compliance matching to native vessels

RM Nezarati, MB Eifert, DK Dempsey… - … Research Part B …, 2015 - Wiley Online Library
Coronary artery bypass grafting is one of the most commonly performed major surgeries in
the United States. Autologous vessels such as the saphenous vein are the current gold …

Endothelial cell seeding of a 4-mm ID polyurethane vascular graft

C Fields, A Cassano, C Allen, A Meyer… - Journal of …, 2002 - journals.sagepub.com
We evaluated the extent (luminal coverage) of the endothelial cell (EC) lining/neointimal
development and the thromboresistance of electrostatically EC seeded small diameter …

Healing characteristics of electrospun polyurethane grafts with various porosities

H Bergmeister, C Schreiber, C Grasl, I Walter… - Acta biomaterialia, 2013 - Elsevier
Pore size and porosity control the rate and depth of cellular migration in electrospun
vascular fabrics and thus have a strong impact on long-term graft success. In this study we …

Assessment of the mechanical properties and biocompatibility of a new electrospun polyurethane vascular prosthesis

W He, ZJ Hu, AW Xu, HH Yin, JS Wang… - … Fang yi ke da xue xue …, 2011 - europepmc.org
Objective To develop a small-caliber vascular grafts and study its morphologies, mechanical
properties and biocompatibility. Methods The effects of electrospinning conditions on the …

Combining electrospun fiber mats and bioactive coatings for vascular graft prostheses

H Savoji, M Maire, P Lequoy, B Liberelle… - …, 2017 - ACS Publications
The patency of small-diameter (< 6 mm) synthetic vascular grafts (VGs) is still limited by the
absence of a confluent, blood flow-resistant monolayer of endothelial cells (ECs) on the …

Pilot mouse study of 1 mm inner diameter (ID) vascular graft using electrospun poly (ester urea) nanofibers

Y Gao, T Yi, T Shinoka, YU Lee… - Advanced …, 2016 - Wiley Online Library
An off‐the‐shelf, small diameter tissue engineered vascular graft (TEVG) would be
transformative to surgeons in multiple subspecialties. Herein, the results of a small diameter …