Drugs in clinical trials for Alzheimer's disease: the major trends
SO Bachurin, EV Bovina… - Medicinal research …, 2017 - Wiley Online Library
Alzheimer's disease (AD) is characterized by a chronic and progressive neurodegenerative
process resulting from the intracellular and extracellular accumulation of fibrillary proteins …
process resulting from the intracellular and extracellular accumulation of fibrillary proteins …
New treatment strategies for Alzheimer's disease: is there a hope?
I Aprahamian, F Stella, OV Forlenza - Indian Journal of Medical …, 2013 - journals.lww.com
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease, and
corresponds to the most common cause of dementia worldwide. Although not fully …
corresponds to the most common cause of dementia worldwide. Although not fully …
Current perspectives on pharmacotherapy of Alzheimer's disease
K Chopra, S Misra, A Kuhad - Expert opinion on pharmacotherapy, 2011 - Taylor & Francis
Introduction: Alzheimer's disease (AD) is a daunting public health threat that has prompted
the scientific community's ongoing efforts to decipher the underlying disease mechanism …
the scientific community's ongoing efforts to decipher the underlying disease mechanism …
Alzheimer's disease (AD) therapeutics–1: Repeated clinical failures continue to question the amyloid hypothesis of AD and the current understanding of AD causality
K Mullane, M Williams - Biochemical Pharmacology, 2018 - Elsevier
Deposits of amyloid plaques and neurofibrillary tangles of aggregated tau in the brain
represent key hallmarks of the neurodegenerative disorder, Alzheimer's Disease (AD) and …
represent key hallmarks of the neurodegenerative disorder, Alzheimer's Disease (AD) and …
Therapeutics of Alzheimer's disease: Past, present and future
Alzheimer's disease (AD) is the most common cause of dementia worldwide. The etiology is
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …
Clinical trials in Alzheimer's disease: a hurdle in the path of remedy
AE Oxford, ES Stewart, TT Rohn - International Journal of …, 2020 - Wiley Online Library
Human clinical trials seek to ameliorate the disease states and symptomatic progression of
illnesses that, as of yet, are largely untreatable according to clinical standards. Ideally …
illnesses that, as of yet, are largely untreatable according to clinical standards. Ideally …
Advances in the therapy of Alzheimer's disease: targeting amyloid beta and tau and perspectives for the future
H Hampel, LS Schneider, E Giacobini… - Expert review of …, 2015 - Taylor & Francis
Worldwide multidisciplinary translational research has led to a growing knowledge of the
genetics and molecular pathogenesis of Alzheimer's disease (AD) indicating that …
genetics and molecular pathogenesis of Alzheimer's disease (AD) indicating that …
Therapeutic strategies for Alzheimer's disease in clinical trials
Alzheimer's disease (AD) is considered to be the most common cause of dementia and is an
incurable, progressive neurodegenerative disorder. Current treatment of the disease …
incurable, progressive neurodegenerative disorder. Current treatment of the disease …
Alzheimer's therapeutics: continued clinical failures question the validity of the amyloid hypothesis—but what lies beyond?
K Mullane, M Williams - Biochemical pharmacology, 2013 - Elsevier
The worldwide incidence of Alzheimer's disease (AD) is increasing with estimates that 115
million individuals will have AD by 2050, creating an unsustainable healthcare challenge …
million individuals will have AD by 2050, creating an unsustainable healthcare challenge …
Current treatment and recent clinical research in Alzheimer's disease
J Neugroschl, M Sano - Mount Sinai Journal of Medicine: A …, 2010 - Wiley Online Library
The transition from either epidemiological observation or the bench to rigorously tested
clinical trials in patients with Alzheimer's disease is crucial in understanding which …
clinical trials in patients with Alzheimer's disease is crucial in understanding which …