Drugs in clinical trials for Alzheimer's disease: the major trends

SO Bachurin, EV Bovina… - Medicinal research …, 2017 - Wiley Online Library
Alzheimer's disease (AD) is characterized by a chronic and progressive neurodegenerative
process resulting from the intracellular and extracellular accumulation of fibrillary proteins …

New treatment strategies for Alzheimer's disease: is there a hope?

I Aprahamian, F Stella, OV Forlenza - Indian Journal of Medical …, 2013 - journals.lww.com
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease, and
corresponds to the most common cause of dementia worldwide. Although not fully …

Current perspectives on pharmacotherapy of Alzheimer's disease

K Chopra, S Misra, A Kuhad - Expert opinion on pharmacotherapy, 2011 - Taylor & Francis
Introduction: Alzheimer's disease (AD) is a daunting public health threat that has prompted
the scientific community's ongoing efforts to decipher the underlying disease mechanism …

Alzheimer's disease (AD) therapeutics–1: Repeated clinical failures continue to question the amyloid hypothesis of AD and the current understanding of AD causality

K Mullane, M Williams - Biochemical Pharmacology, 2018 - Elsevier
Deposits of amyloid plaques and neurofibrillary tangles of aggregated tau in the brain
represent key hallmarks of the neurodegenerative disorder, Alzheimer's Disease (AD) and …

Therapeutics of Alzheimer's disease: Past, present and future

R Anand, KD Gill, AA Mahdi - Neuropharmacology, 2014 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia worldwide. The etiology is
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …

Clinical trials in Alzheimer's disease: a hurdle in the path of remedy

AE Oxford, ES Stewart, TT Rohn - International Journal of …, 2020 - Wiley Online Library
Human clinical trials seek to ameliorate the disease states and symptomatic progression of
illnesses that, as of yet, are largely untreatable according to clinical standards. Ideally …

Advances in the therapy of Alzheimer's disease: targeting amyloid beta and tau and perspectives for the future

H Hampel, LS Schneider, E Giacobini… - Expert review of …, 2015 - Taylor & Francis
Worldwide multidisciplinary translational research has led to a growing knowledge of the
genetics and molecular pathogenesis of Alzheimer's disease (AD) indicating that …

Therapeutic strategies for Alzheimer's disease in clinical trials

J Godyń, J Jończyk, D Panek, B Malawska - Pharmacological Reports, 2016 - Elsevier
Alzheimer's disease (AD) is considered to be the most common cause of dementia and is an
incurable, progressive neurodegenerative disorder. Current treatment of the disease …

Alzheimer's therapeutics: continued clinical failures question the validity of the amyloid hypothesis—but what lies beyond?

K Mullane, M Williams - Biochemical pharmacology, 2013 - Elsevier
The worldwide incidence of Alzheimer's disease (AD) is increasing with estimates that 115
million individuals will have AD by 2050, creating an unsustainable healthcare challenge …

Current treatment and recent clinical research in Alzheimer's disease

J Neugroschl, M Sano - Mount Sinai Journal of Medicine: A …, 2010 - Wiley Online Library
The transition from either epidemiological observation or the bench to rigorously tested
clinical trials in patients with Alzheimer's disease is crucial in understanding which …