Materials and Methods A total of 36 sIA samples, comprising 16 unruptured and 20 ruptured
cases, were obtained during surgical clip ligation at Helsinki University Hospital …

Saccular intracranial aneurysm (sIA) rupture leads to a disabling subarachnoid hemorrhage.
Chronic inflammation and lipid accumulation in the sIA wall contribute to wall degenerative …

Saccular intracranial aneurysm (sIA) rupture leads to subarachnoid haemorrhage and is
preceded by chronic inflammation and atherosclerotic changes of the sIA wall. Increased …

Background Intracranial aneurysms (IA) are increasingly recognized as a disease driven by
chronic inflammation. Recent research has identified key mediators and processes …

Introduction Intracranial aneurysms (IAs) remain a devastating clinical challenge, and the
pathogenesis of IA formation and progression continues to be unclear. Biomarker analysis …

Background Rupture of a saccular intracranial aneurysm (sIA) causes an often fatal
subarachnoid hemorrhage (SAH). Why some sIAs rupture remains unknown. Since sIA walls …

Saccular intracranial aneurysms (sIA) are pouch-like pathological dilatations of intracranial
arteries that develop when the cerebral artery wall becomes too weak to resist …

BACKGROUND: Aneurysmal subarachnoid hemorrhage, almost always from saccular
intracranial aneurysm (sIA), is a devastating form of stroke that affects the working-age …

Rupture of a saccular intracranial artery aneurysm (IA) causes subarachnoid hemorrhage, a
significant cause of stroke and death. The current treatment options, endovascular coiling …

Saccular intracranial aneurysm (sIA) rupture is often fatal. Rupture-prone sIA walls are
infiltrated by macrophages expressing hemoglobin-receptor CD163, suggesting a role for …