Mitochondrial DNA in inflammation and immunity
Mitochondria are cellular organelles that orchestrate a vast range of biological processes,
from energy production and metabolism to cell death and inflammation. Despite this …
from energy production and metabolism to cell death and inflammation. Despite this …
[HTML][HTML] Advances in the understanding of mitochondrial DNA as a pathogenic factor in inflammatory diseases
Mitochondrial DNA (mtDNA) has many similarities with bacterial DNA because of their
shared common ancestry. Increasing evidence demonstrates mtDNA to be a potent danger …
shared common ancestry. Increasing evidence demonstrates mtDNA to be a potent danger …
Metabolism and innate immunity meet at the mitochondria
A Bahat, T MacVicar, T Langer - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Mitochondria are master regulators of metabolism and have emerged as key signalling
organelles of the innate immune system. Each mitochondrion harbours potent agonists of …
organelles of the innate immune system. Each mitochondrion harbours potent agonists of …
Mitochondrial DNA in innate immune responses and inflammatory pathology
Mitochondrial DNA (mtDNA)—which is well known for its role in oxidative phosphorylation
and maternally inherited mitochondrial diseases—is increasingly recognized as an agonist …
and maternally inherited mitochondrial diseases—is increasingly recognized as an agonist …
Emerging role of mitochondrial DNA as a major driver of inflammation and disease progression
Inflammation benefits the host by promoting the elimination of invading pathogens and
clearance of cellular debris after tissue injury. Inflammation also stimulates tissue repair and …
clearance of cellular debris after tissue injury. Inflammation also stimulates tissue repair and …
Molecular mechanisms of mtDNA-mediated inflammation
A De Gaetano, K Solodka, G Zanini, V Selleri… - Cells, 2021 - mdpi.com
Besides their role in cell metabolism, mitochondria display many other functions.
Mitochondrial DNA (mtDNA), the own genome of the organelle, plays an important role in …
Mitochondrial DNA (mtDNA), the own genome of the organelle, plays an important role in …
Mitochondrial DNA in the regulation of innate immune responses
C Fang, X Wei, Y Wei - Protein & cell, 2016 - academic.oup.com
Mitochondrion is known as the energy factory of the cell, which is also a unique mammalian
organelle and considered to be evolved from aerobic prokaryotes more than a billion years …
organelle and considered to be evolved from aerobic prokaryotes more than a billion years …
Mitochondrial DNA release in innate immune signaling
According to the endosymbiotic theory, most of the DNA of the original bacterial
endosymbiont has been lost or transferred to the nucleus, leaving a much smaller (∼ 16 kb …
endosymbiont has been lost or transferred to the nucleus, leaving a much smaller (∼ 16 kb …
Assessing mitochondrial DNA release into the cytosol and subsequent activation of innate immune‐related pathways in mammalian cells
JD Bryant, Y Lei, JJ VanPortfliet, AD Winters… - Current …, 2022 - Wiley Online Library
Mitochondria have emerged as key drivers of mammalian innate immune responses,
functioning as signaling hubs to trigger inflammation and orchestrating metabolic switches …
functioning as signaling hubs to trigger inflammation and orchestrating metabolic switches …
Mitochondrial DNA stress signalling protects the nuclear genome
The mammalian genome comprises nuclear DNA (nDNA) derived from both parents and
mitochondrial DNA (mtDNA) that is maternally inherited and encodes essential proteins …
mitochondrial DNA (mtDNA) that is maternally inherited and encodes essential proteins …