Neurofilament proteins have been validated as specific body fluid biomarkers of neuro-
axonal injury. The advent of highly sensitive analytical platforms that enable reliable …

Neuroaxonal damage is the pathological substrate of permanent disability in various
neurological disorders. Reliable quantification and longitudinal follow-up of such damage …

Biomarkers of neurodegeneration and neuronal injury have the potential to improve
diagnostic accuracy, disease monitoring, prognosis, and measure treatment efficacy …

Interest in neurofilaments has risen sharply in recent years with recognition of their potential
as biomarkers of brain injury or neurodegeneration in CSF and blood. This is in the context …

One of the most pressing challenges in the clinical research of neurodegenerative diseases
(NDDs) is the validation and standardization of pathophysiological biomarkers for different …

Biomarkers of axonal degeneration have the potential to improve our capacity to predict and
monitor neurological outcome in multiple sclerosis (MS) patients. Neurofilament proteins …

Objective Neuronal damage is the morphological substrate of persisting neurological
disability. Neurofilaments (Nf) are cytoskeletal proteins of neurons and their release into …

Neurobiomarkers have attracted significant attention over the last ten years. One promising
biomarker is the neurofilament light chain protein (NfL). Since the introduction of …

Introduction Neurodegenerative processes occur from the beginning of multiple sclerosis,
contribute to irreversible clinical disability and are only partially addressed by current …

Motor neuron disease includes a heterogeneous group of relentless progressive
neurological disorders defined and characterized by the degeneration of motor neurons …