The clinical management of familial cancer begins with recognition of patterns of cancer
occurrence suggestive of genetic susceptibility in a proband or pedigree, to enable …

Mutations in hereditary cancer syndromes account for a modest fraction of all cancers;
however, identifying patients with these germline mutations offers tremendous health …

Since the third edition of this book, the rapid development in our understanding of inherited
cancer susceptibility has continued apace. This edition is the first to be published by …

Cancer Genomics addresses how recent technological advances in genomics are shaping
how we diagnose and treat cancer. Built on the historical context of cancer genetics over the …

Cancer is among the leading causes of death and disfigurement worldwide with an
estimated global incidence of 14 million and~ 8.2 million cancer-related deaths per annum …

Introduction: Constitutional mutations in genes controlling DNA repair, cell-cycle regulation
and cell apoptosis can determine an individual's tendency to develop cancer. Hereditary …

The last decade has witnessed dramatic advances in our understanding of the molecular
changes that underlie both the development of sporadic cancers and the inheritance of …

Abstract Geneticists estimate that 5% to 10% of all cancers diagnosed in the pediatric age
range occur in children born with a genetic mutation that directly increases their lifetime risk …

Molecular testing for hereditary cancers has rapidly advanced over the past two decades.
Next‐generation sequencing has been widely adopted, which has made molecular testing …

Hereditary cancer syndromes are estimated to account for up to 10% of all new cancer
diagnoses in children and adults 1-4. Given the current incidence of pediatric cancer, this …