Following initiation of coagulation as part of the hemostatic response to injury, thrombin is
generated from its inactive precursor prothrombin by factor Xa as part of the prothrombinase …

After generation from prothrombin, thrombin plays multiple roles in the blood coagulation
cascade that are mediated by interaction with a number of physiologic substrates, effectors …

Thrombin has both beneficial and harmful effects. In order of importance, at very low
concentrations,[alpha]-thrombin firstly amplifies its own generation through the activation of …

Procoagulant a-thrombin is the central bioregulatory enzyme in hemostasis. 14 Hemostasis
is the containment of circulating blood necessary for supplying essential substances and …

Precise modulation of thrombin activity throughout the hemostatic response is essential for
efficient cessation of bleeding while preventing inappropriate clot growth or dissemination …

The fundamental importance of thrombin in biology and medicine has made it one of the
most extensively studied of all proteases. Thrombin performs essential functions in …

Following vascular injury, blood loss is controlled by the mechanisms of hemostasis. During
this process, the serine proteinase, thrombin, is generated both locally and rapidly at sites of …

Thrombin is the final protease generated in the blood coagulation cascade, and is the only
factor capable of cleaving fibrinogen to create a fibrin clot. Unlike every other coagulation …

The prothrombinase complex, composed of factor Xa and factor Va assembled on a
membrane surface, catalyzes the proteolytic formation of thrombin during blood coagulation …

The central event of the hemostatic process is the generation of thrombin through the tissue
factor pathway. This is a highly regulated, dynamic process in which thrombin itself plays …