High-throughput optical assays for sensing serine hydrolases in living systems and their applications
Q Jin, LL Song, LL Ding, J Zhang, DD Wang… - TrAC Trends in …, 2022 - Elsevier
Serine hydrolases (SHs) comprise a large family of hydrolytic enzymes that play crucial roles
in numerous physiological and pathological processes, such as blood coagulation, cancer …
in numerous physiological and pathological processes, such as blood coagulation, cancer …
Serine Hydrolase Activity‐Based Probes for Use in Chemical Proteomics
B Racioppo, N Qiu, A Adibekian - Israel Journal of Chemistry, 2023 - Wiley Online Library
Serine hydrolases (SHs) comprise a large superfamily of enzymes that play critical roles in
many biological processes. Despite their importance, many SHs remain uncharacterized …
many biological processes. Despite their importance, many SHs remain uncharacterized …
Strategies for tuning the selectivity of chemical probes that target serine hydrolases
Serine hydrolases comprise a large family of enzymes that have diverse roles in key cellular
processes, such as lipid metabolism, cell signaling, and regulation of post-translation …
processes, such as lipid metabolism, cell signaling, and regulation of post-translation …
Most recent advances on enzyme‐activatable optical probes for bioimaging
J Mei, H Tian - Aggregate, 2021 - Wiley Online Library
Enzymes are essential biological elements that play vital roles in many key cellular events
and physiological processes. The dysregulation of enzyme activity broadly occurs in a large …
and physiological processes. The dysregulation of enzyme activity broadly occurs in a large …
Discovery and evaluation of new activity‐based probes for serine hydrolases
Serine hydrolases play crucial biological roles and are important therapeutic targets in many
clinical applications. Activity‐based protein profiling of serine hydrolases by using …
clinical applications. Activity‐based protein profiling of serine hydrolases by using …
Chemically diverse activity-based probes with unexpected inhibitory mechanisms targeting trypsin-like serine proteases
A Ramos-Llorca, L Decraecker, VMY Cacheux… - Frontiers in …, 2023 - frontiersin.org
Activity-based probes (ABP) are molecules that bind covalently to the active form of an
enzyme family, making them an attractive tool for target and biomarker identification and …
enzyme family, making them an attractive tool for target and biomarker identification and …
Comparative assessment of substrates and activity based probes as tools for non-invasive optical imaging of cysteine protease activity
Recent advances in the field of non-invasive optical imaging have included the development
of contrast agents that report on the activity of enzymatic targets associated with disease …
of contrast agents that report on the activity of enzymatic targets associated with disease …
Sensitive sulfide ion detection by optofluidic catalytic laser using horseradish peroxidase (HRP) enzyme
We report an optofluidic catalytic laser for sensitive sulfide ion detection. In the catalytic
reaction, horseradish peroxidase (HRP) enzyme is used for catalyzing the non-fluorescent …
reaction, horseradish peroxidase (HRP) enzyme is used for catalyzing the non-fluorescent …
Direct visualization of serine hydrolase activities in complex proteomes using fluorescent active site‐directed probes
MP Patricelli, DK Giang, LM Stamp… - PROTEOMICS …, 2001 - Wiley Online Library
The field of biochemistry is currently faced with the enormous challenge of assigning
functional significance to more than thirty thousand predicted protein products encoded by …
functional significance to more than thirty thousand predicted protein products encoded by …
[HTML][HTML] Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives
Q Jin, JJ Wu, Y Wu, H Li, M Finel, D Wang… - Acta pharmaceutica sinica …, 2022 - Elsevier
Abstract Drug-metabolizing enzymes (DMEs), a diverse group of enzymes responsible for
the metabolic elimination of drugs and other xenobiotics, have been recognized as the …
the metabolic elimination of drugs and other xenobiotics, have been recognized as the …