[HTML][HTML] Breath Biopsy® to Identify Exhaled Volatile Organic Compounds Biomarkers for Liver Cirrhosis Detection

G Ferrandino, G De Palo, A Murgia… - Journal of Clinical …, 2023 - ncbi.nlm.nih.gov
Methods To identify candidate biomarkers we compared 46 breath samples from cirrhosis
patients and 42 from controls. Collection and analysis used Breath Biopsy OMNI™ …

[HTML][HTML] A profile of volatile organic compounds in exhaled air as a potential non-invasive biomarker for liver cirrhosis

KE Pijls, A Smolinska, DMAE Jonkers, JW Dallinga… - Scientific reports, 2016 - nature.com
Early diagnosis of liver cirrhosis may prevent progression and development of
complications. Liver biopsy is the current standard, but is invasive and associated with …

[HTML][HTML] Breath biopsy assessment of liver disease using an exogenous volatile organic compound—toward improved detection of liver impairment

G Ferrandino, I Orf, R Smith, M Calcagno… - Clinical and …, 2020 - journals.lww.com
METHODS: We compared the exhaled breath of 40 controls, 32 cirrhotic patients, and 12
cirrhotic patients with HCC using the Breath Biopsy platform. Breath samples were analyzed …

[HTML][HTML] Volatomic analysis identifies compounds that can stratify non-alcoholic fatty liver disease

R Sinha, KA Lockman, NZM Homer, E Bower… - JHEP Reports, 2020 - Elsevier
Background & aims Analysis of volatile organic compounds (VOCs) in exhaled
breath,'volatomics', provides opportunities for non-invasive biomarker discovery and novel …

[PDF][PDF] Breath metabolomics provides an accurate and noninvasive approach for screening cirrhosis, primary, and secondary liver tumors

G Miller‐Atkins, LA Acevedo‐Moreno… - Hepatology …, 2020 - Wiley Online Library
Hepatocellular carcinoma (HCC) and secondary liver tumors, such as colorectal cancer liver
metastases are significant contributors to the overall burden of cancer‐related morality …

Breath biomarkers of liver cirrhosis

J Dadamio, S Van den Velde, W Laleman… - … of Chromatography B, 2012 - Elsevier
The diagnosis of asymptomatic cirrhosis in patients with liver disease is of importance to
start screening for complications in due time. Liver biopsy is neither sensitive nor practical …

[HTML][HTML] Exhaled breath analysis in hepatology: State-of-the-art and perspectives

A De Vincentis, U Vespasiani-Gentilucci… - World journal of …, 2019 - ncbi.nlm.nih.gov
Liver disease is characterized by breath exhalation of peculiar volatile organic compounds
(VOCs). Thanks to the availability of sensitive technologies for breath analysis, this empiric …

[HTML][HTML] Volatile biomarkers in breath associated with liver cirrhosis—comparisons of pre-and post-liver transplant breath samples

RF Del Río, ME O'Hara, A Holt, P Pemberton, T Shah… - …, 2015 - thelancet.com
Background The burden of liver disease in the UK has risen dramatically and there is a need
for improved diagnostics. Aims To determine which breath volatiles are associated with the …

[HTML][HTML] Breath-taking perspectives and preliminary data toward early detection of chronic liver diseases

A Murgia, Y Ahmed, K Sweeney, L Nicholson-Scott… - Biomedicines, 2021 - mdpi.com
The gold standard method for chronic liver diseases diagnosis and staging remains liver
biopsy, despite the spread of less invasive surrogate modalities based on imaging and …

[HTML][HTML] Exogenous Volatile Organic Compound (EVOC®) Breath Testing Maximizes Classification Performance for Subjects with Cirrhosis and Reveals Signs of …

G Ferrandino, F Ricciardi, A Murgia, I Banda… - Biomedicines, 2023 - mdpi.com
Background: Cirrhosis detection in primary care relies on low-performing biomarkers.
Consequently, up to 75% of subjects with cirrhosis receive their first diagnosis with …