We propose a peptide binding hypothesis of psoriatic arthritis based on a shared pattern of
negative charge in the 'B'pocket of the HLA-B and HLA-C molecules encoded by the …

Objective Rigorously ascertained cases of psoriatic arthritis in subjects presenting to a
rheumatology unit were compared with cases of psoriasis in subjects presenting to a …

We sought to validate and extend the findings of a 282 psoriatic arthritis patient cohort from
Dublin using a 219 patient cohort from Bath. The central finding of this study was that several …

HLA molecules play a central role in the immune response by presenting processed
antigenic peptides to T cells. In the case of rheumatoid arthritis (RA), a specific sequence …

On behalf of my colleagues, I deeply appreciate Dr. Dalbeth and colleagues' interest in our
work1. The authors studied the relative role of the HLA-B27 antigen on the clinical …

This review is a simple guide to the deeper meaning of the association of a disease with a
particular HLA allele. We will first review some principles of the function of the adaptive …

On behalf of my colleagues, I deeply appreciate Dr. Dalbeth and colleagues' interest in our
work1. The authors studied the relative role of the HLA-B27 antigen on the clinical …

Objective: Psoriasis of early onset (type I; age of onset⩽ 40 years) is associated with HLA-
Cw* 06 while the shared epitope (SE) is associated with rheumatoid arthritis susceptibility …

Reactive arthritis (ReA) is associated with the MHC class-I molecule HLA-B27 and caused
by certain Gram-negative bacteria. The mechanism by which HLA-B27 confers a higher …

Some 25 years ago, when purified HLA class I allotypes were first being analyzed, of major
concern was that the papain used for solubilization might produce a mess of proteolytic …