Many metabolic processes require metal ions as cofactors making them essential for life. As
elevated levels of metals are toxic, cells have mechanisms to maintain metal homeostasis …

Trace metals, like Fe and Mn, are essential to both humans and pathogens. In nutritional
immunity, our body withholds metals from pathogens to starve them and protect us, while the …

Metals such as Fe, Cu, Zn, and Mn are essential trace nutrients for all kingdoms of life,
including microbial pathogens and their hosts. During infection, the mammalian host …

Human NRAMP1 (SLC11A1) and DMT1 (SLC11A2) metal‐ion transporters play
nonredundant roles in host defense against infection and in iron homeostasis, respectively …

Cryptococcus neoformans is an important human opportunistic pathogen and a facultative
intracellular parasite, particularly in HIV-infected individuals. Little is known about metal ion …

Siderophores are small organic compounds with high affinity for ferric iron. Microorganisms
commonly acquire iron via siderophore secretion and uptake. Here we report the …

In Saccharomyces cerevisiae, the transcription factor Aft1p plays a central role in regulating
many genes involved in iron acquisition and utilization. An aft1 Δ mutant exhibits severely …

The Nramp (natural resistance associated macrophage protein) family of transition metal ion
transporters is an important class of secondary active transporters involved in metal …

Iron is an essential nutrient for nearly all organisms, but iron overdose is toxic. The human
commensal‐pathogenic fungus Candida albicans traverses host niches with markedly …

Transition metal ions such as copper, iron, manganese and zinc serve as essential cofac
tors for a variety of biological processes including cell energetics, gene regulation and …