Senile osteoporosis (SOP) is a systemic bone disease that is significantly associated with
age and eventually leads to deteriorated bone strength and increased fracture risk. Urolithin …

Osteoporosis (OP) is characterized by decreased trabecular bone volume and
microarchitectural deterioration in the medullary cavity. Urolithin A (UA) is a biologically …

Urolithin A (UA) is an intestinal microbial metabolite derived from ellagitannins and a
promising agent for treating osteoarthritis. However, its effects on osteoporosis are unclear …

Osteoporosis (OP) has severely affected human health, which is characterized by abnormal
differentiation of osteoclasts. Urolithin B (UB), as a potential natural drug, has been reported …

Objectives The main target of current drugs for alleviating bone loss is osteoclasts. However,
the long‐term application of such drugs will also cause side effects. Therefore, it is of great …

As a critical regulator of bone resorption. osteoclastogenesis is closely associated with
osteoporosis (OP) and commonly induced by receptor activator of nuclear factor-κB ligand …

With the growth of the aging population, osteoporosis is becoming a global health problem.
Ursolic acid (UA) is an active ingredient existed in a variety of foods and nature plants and …

Background Puerarin exerts therapeutic effect on osteoporosis due to its inhibitory effect on
the formation of osteoclasts. Puerarin is also widely established as an autophagy inhibitor …

Osteoporosis (OP) is the most common bone disorder worldwide, especially in
postmenopausal women. However, many OP drugs are not suitable for long term use due to …

Lycorine, a plant alkaloid, exhibits anti‐inflammatory activity by acting in macrophages that
share precursor cells with osteoclasts (OCs). We hypothesized that lycorine might decrease …