Inhibition of late mRNA synthesis in the hippocampus impairs consolidation and reconsolidation of spatial memory in male rats

WC da Silva, JS Bonini - Neurobiology of Learning and Memory, 2022 - Elsevier
It has already been shown that both consolidation and reconsolidation of long-term
memories require protein synthesis and de novo gene transcription immediately after …

Inhibition of mRNA synthesis in the hippocampus impairs consolidation and reconsolidation of spatial memory

WC Da Silva, JS Bonini, LRM Bevilaqua… - …, 2008 - Wiley Online Library
Using two different mRNA synthesis inhibitors, we show that blockade of hippocampal gene
expression during restricted posttraining or postretrieval time windows hinders retention of …

Inhibition of transcription and translation in dorsal hippocampus does not interfere with consolidation of memory of intense training

AC Medina, ME Torres-García… - … of Learning and …, 2019 - Elsevier
Findings of several experiments indicate that many treatments that typically interfere with
memory consolidation are ineffective in preventing or attenuating memory induced by …

Reconsolidation of a long-term spatial memory is impaired by cycloheximide when reactivated with a contextual latent learning trial in male and female rats

RW Flint Jr, S Valentine, D Papandrea Jr - Neuroscience, 2007 - Elsevier
Reconsolidation of long-term memory has become a topic of great interest in recent years,
and has the potential to provide important information regarding memory processes and the …

[PDF][PDF] Memory reconsolidation: sensitivity of spatial memory to inhibition of protein synthesis in dorsal hippocampus during encoding and retrieval

RGM Morris, J Inglis, JA Ainge, HJ Olverman, J Tulloch… - Neuron, 2006 - cell.com
Reconsolidation is a putative neuronal process in which the retrieval of a previously
consolidated memory returns it to a labile state that is once again subject to stabilization …

Reactivation with a simple exposure to the experimental environment is sufficient to induce reconsolidation requiring protein synthesis in the hippocampal CA3 region …

J Artinian, XD Jaeger, L Fellini, P Saint Blanquat… - …, 2007 - Wiley Online Library
Our understanding of the memory reconsolidation process is at an earlier stage than that of
consolidation. For example, it is unclear if, as for memory consolidation, reconsolidation of a …

Retrieval induces hippocampal-dependent reconsolidation of spatial memory

JI Rossato, LRM Bevilaqua, JH Medina… - Learning & …, 2006 - learnmem.cshlp.org
Nonreinforced retrieval can cause extinction and/or reconsolidation, two processes that
affect subsequent retrieval in opposite ways. Using the Morris water maze task we show that …

Inactivation of the dorsal hippocampus or the medial prefrontal cortex impairs retrieval but has differential effect on spatial memory reconsolidation

JI Rossato, CA Köhler, A Radiske… - Neurobiology of learning …, 2015 - Elsevier
Active memories can incorporate new information through reconsolidation. However, the
notion that memory retrieval is necessary for reconsolidation has been recently challenged …

[HTML][HTML] Learning-induced ribosomal RNA is required for memory consolidation in mice—Evidence of differentially expressed rRNA variants in learning and memory

KD Allen, MJ Regier, C Hsieh, P Tsokas, M Barnard… - PLoS …, 2018 - journals.plos.org
The transition from short-term to long-term forms of synaptic plasticity requires protein
synthesis and new gene expression. Most efforts to understand experience-induced …

On the participation of mTOR in recognition memory

JC Myskiw, JI Rossato, LRM Bevilaqua… - Neurobiology of learning …, 2008 - Elsevier
Evidence indicates that activation of the neuronal protein synthesis machinery is required in
areas of the brain relevant to memory for consolidation and persistence of the mnemonic …