New insights into T cells and their signature cytokines in atopic dermatitis

A Wang, N Xu Landén - IUBMB life, 2015 - Wiley Online Library
An imbalance of the adaptive immune system mediated by various T cells plays a pivotal
role in the pathogenesis of atopic dermatitis (AD). Traditionally, sustained exposure of …

Cellular and molecular mechanisms in atopic dermatitis

MK Oyoshi, R He, L Kumar, J Yoon, RS Geha - Advances in immunology, 2009 - Elsevier
Atopic dermatitis (AD) is a pruritic inflammatory skin disease associated with a personal or
family history of allergy. The prevalence of AD is on the rise and estimated at∼ 17% in the …

T helper cell subsets in the development of atopic dermatitis.

MJ Turner, JB Travers, MH Kaplan - Journal of drugs in dermatology …, 2012 - europepmc.org
The pathogenesis of atopic dermatitis (AD) requires the orchestration of multiple immune
cells that mediate inflammation and tissue remodeling in the skin. T helper cell subsets that …

[HTML][HTML] Multiple roles for cytokines in atopic dermatitis: from pathogenic mediators to endotype-specific biomarkers to therapeutic targets

L Fania, G Moretta, F Antonelli, E Scala… - International Journal of …, 2022 - mdpi.com
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases, which
generally presents with intense itching and recurrent eczematous lesions. AD affects up to …

[HTML][HTML] Pathomechanism of atopic dermatitis in the perspective of T cell subsets and skin barrier functions–“Which comes first, the chicken or the egg?”

K Kabashima - Dermatologica Sinica, 2012 - Elsevier
Atopic dermatitis (AD) is a common skin condition that is characterized by a complex,
heterogeneous pathogenesis. The possible candidates for its pathogenesis include skin …

Immune dysregulation in atopic dermatitis

PY Ong, DMY Leung - Current allergy and asthma reports, 2006 - Springer
Atopic dermatitis is a chronic inflammatory skin disease that causes significant morbidity in
affected individuals. It is characterized by dysregulated immune responses that consist of an …

[HTML][HTML] Current insights into immunology and novel therapeutics of atopic dermatitis

HA Kader, M Azeem, SA Jwayed, A Al-Shehhi… - Cells, 2021 - mdpi.com
Atopic dermatitis (AD) is one of the most prevalent inflammatory disease among non-fatal
skin diseases, affecting up to one fifth of the population in developed countries. AD is …

The role of cytokines/chemokines in the pathogenesis of atopic dermatitis

K Yamanaka, H Mizutani - Pathogenesis and Management of Atopic …, 2011 - karger.com
Atopic dermatitis (AD) is the most common and relapsing allergic disease of the skin. AD is
characterized by a predominant expression of Th2-type cytokines associated with increased …

[HTML][HTML] Th2 cytokines and atopic dermatitis

EB Brandt, U Sivaprasad - Journal of clinical & cellular immunology, 2011 - ncbi.nlm.nih.gov
Atopic dermatitis (AD), a chronic relapsing inflammatory skin disease, is increasing in
prevalence around the world. Intensive research is ongoing to understand the mechanisms …

Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms

PM Elias, Y Hatano, ML Williams - Journal of Allergy and Clinical …, 2008 - Elsevier
Until quite recently, the pathogenesis of atopic dermatitis (AD) has been attributed to primary
abnormalities of the immune system. Intensive study revealed the key roles played by …