Importance Documentation of muscle pathology compatible with targeting of sarcolemmal
aquaporin-4 (AQP4) by complement-activating IgG implies involvement of organs beyond …

Neuromyelitis optica (NMO) is an autoimmune inflammatory CNS disease associated with
pathogenic aquaporin-4 autoantibodies (AQP4-IgG); optic neuritis (ON) and myelitis are …

Importance Using an aquaporin-4 (AQP4) M1-isoform–specific enzyme-linked
immunosorbent assay (ELISA) and a fixed transfected cell-based assay (CBA), we tested …

Background: Neuromyelitis optica (NMO) is a disease of the CNS characterized by severe
optic neuritis and longitudinally extended transverse myelitis. Recent studies suggest that …

Abstract Background: Neuromyelitis optica (NMO, Devic syndrome) is an inflammatory
disorder of the central nervous system of putative autoimmune etiology that primarily affects …

Background Neuromyelitis optica spectrum disorders are severe autoimmune inflammatory
diseases of the central nervous system associated with the presence of immunoglobulin G …

Neuromyelitis optica is an inflammatory demyelinating disorder of the CNS. The discovery of
circulating IgG1 antibodies against the astrocyte water channel protein aquaporin 4 (AQP4) …

Background: Neuromyelitis optica (NMO, Devic syndrome) and myasthenia gravis (MG) are
rare antibody-mediated autoimmune disorders. Concurrent incidence has been reported in …

Objective: To 1) determine, using contemporary recombinant antigen–based assays, the
aquaporin-4 (AQP4)–immunoglobulin G (IgG) detection rate in sequential sera of patients …

Background There is increasing recognition of antibody-mediated immunotherapy-
responsive neurologic diseases and a need for appropriate immunoassays. Objectives To …