Cells are subjected to endogenous [eg, reactive oxygen species (ROS), replication stress]
and exogenous insults (eg, UV light, ionizing radiation, and certain chemicals), which can …

Tissue-specific extracellular matrices (ECMs) are crucial for normal development and tissue
function, and mutations in ECM genes result in a wide range of serious inherited connective …

The extracellular matrix (ECM) provides signalling cues that regulate cell behaviour and
orchestrate functions of cells in tissue formation and homeostasis. The composition of the …

Considerable evidence exists for oxidative damage to extracellular materials during multiple
human pathologies. Unlike cells, the extracellular compartment of most biological tissues is …

The extracellular matrix (ECM) serves diverse functions and is a major component of the
cellular microenvironment. The ECM is a highly dynamic structure, constantly undergoing a …

Cells are armed with a vast repertoire of antioxidant defense mechanisms to help prevent
the accumulation of oxidative damage. It is becoming increasingly apparent that the cellular …

The extracellular matrix (ECM) is a highly dynamic and heterogeneous structure that plays
multiple roles in living organisms. Its integrity and homeostasis are crucial for normal tissue …

Extracellular matrixes (ECMs) are intricate 3-dimensional macromolecular networks of
unique architectures with regulatory roles in cell morphology and functionality. As a dynamic …

Mutations in the genes for extracellular matrix (ECM) components cause a wide range of
genetic connective tissues disorders throughout the body. The elucidation of mutations and …

The extracellular matrix (ECM) is the noncellular component present within all tissues and
organs, and provides not only essential physical scaffolding for the cellular constituents but …