Somatostatin sst2 receptor knock-out mice: localisation of sst1–5 receptor mRNA and binding in mouse brain by semi-quantitative RT–PCR, in situ hybridisation …

JP Hannon, C Petrucci, D Fehlmann, C Viollet… - …, 2002 - Elsevier
The peptide hormone/neurotransmitter somatostatin (somatotropin release inhibiting factor;
SRIF) and its receptors (sst1–sst5) appear to regulate many physiological functions in the …

Cloning, expression and pharmacological characterisation of the mouse somatostatin sst5 receptor

D Feuerbach, D Fehlmann, C Nunn, S Siehler… - …, 2000 - Elsevier
The mouse somatostatin (somatotropin release inhibiting factor, SRIF) sst5 receptor coding
sequence was cloned from a mouse BALB/c genomic library. It shows 97% and 81 …

Immunohistochemical localization of the somatostatin sst4 receptor in rat brain

IS Selmer, M Schindler, PPA Humphrey, PC Emson - Neuroscience, 2000 - Elsevier
The biological actions of the neuromodulator somatostatin are mediated through a family of
G-protein-coupled receptors, of which five members, sst1–5, have been identified. Although …

Distribution and characterisation of somatostatin receptor mRNA and binding sites in the brain and periphery

D Fehlmann, D Langenegger, E Schuepbach… - Journal of Physiology …, 2000 - Elsevier
The distribution and nature of (somatostatin) SRIF receptors and receptor mRNAs was
studied in the brain and periphery of various laboratory animals using in situ hybridisation …

Characterization and distribution of somatostatin SS-1 and SRIF-1 binding sites in rat brain: identitity with SSTR-2 receptors

P Schoeffter, J Pérez, D Langenegger… - European Journal of …, 1995 - Elsevier
Somatostatin (SRIF) SS-1 binding sites were initially defined in radioligand binding studies
performed in rat brain cerebral cortex membranes using [125I] 204-090 (a radiolabelled Tyr3 …

Somatostatin-induced regulation of SST2A receptor expression and cell surface availability in central neurons: role of receptor internalization

H Boudin, P Sarret, J Mazella… - Journal of …, 2000 - Soc Neuroscience
To investigate the effects of somatostatin (somatotropin release-inhibiting factor, SRIF) on
the regulation of SST2A receptors in mammalian brain, we examined how blockade of SRIF …

Pharmacological identity between somatostatin SS-2 binding sites and SSTR-1 receptors

D Hoyer, J Perez, P Schoeffter, D Langenegger… - European Journal of …, 1995 - Elsevier
Somatostatin (SRIF) SS-2 binding sites were originally defined in rat brain cerebral cortex
membranes using [125I] Tyr11-SRIF-14 in the presence of 120 mM NaCl. These sites were …

Embryonic and postnatal mRNA distribution of five somatostatin receptor subtypes in the rat brain

VS Thoss, J Ferez, D Duc, D Hoyer - Neuropharmacology, 1995 - Elsevier
The messenger RNA (mRNA) expression of somatostatin (SRIF) receptors SSTR-1, SSTR-2,
SSTR-3, SSTR-4 and SSTR-5 (called sst1–5, now) was studied in rat brain between …

First localisation of somatostatin sst4 receptor protein in selected human brain areas: an immunohistochemical study

IS Selmer, M Schindler, PPA Humphrey… - Molecular brain …, 2000 - Elsevier
Somatostatin is known to have diverse neurophysiological effects in the mammalian CNS.
To date, genes for five different receptors, termed sst1–5, have been isolated. Recently …

Preferential expression of sst2A over sst2B somatostatin receptor splice variant in rat brain and pituitary

P Sarret, JM Botto, JP Vincent, J Mazella… - …, 1998 - karger.com
The expression of sst2A and sst2B somatostatin (SRIH) receptor splice variants was
examined by polymerase chain reaction (PCR) in rat brain and pituitary. Two sets of primers …