Inflammasomes are multimeric protein complex that assemble in the cytosol upon microbial
infection or cellular stress. Upon activation, inflammasomes drive the maturation of …

Apoptotic cell death is important for embryonic development, immune cell homeostasis, and
pathogen elimination. Innate immune cells also undergo a very rapid form of cell death …

The inflammasome is a multiprotein complex involved in innate immunity. Activation of the
inflammasome causes the processing and release of the cytokines interleukins 1β and 18. In …

Pyroptosis is a form of lytic inflammatory cell death driven by inflammatory caspase‐1,
caspase‐4, caspase‐5 and caspase‐11. These caspases cleave and activate the pore …

The noncanonical inflammasome induced by intracellular lipopolysaccharide (LPS) leads to
caspase-11-dependent pyroptosis, which is critical for induction of endotoxic shock in mice …

Pathogen-activated and damage-associated molecular patterns activate the inflammasome
in macrophages. We report that mouse macrophages release IL-1β while co-incubated with …

Inflammasomes are cytosolic, multiprotein complexes assembled by members of the NOD-
like receptor (NLR) and PYHIN protein families in response to pathogen-associated …

PANoptosomes are large cell death-inducing complexes that drive a type of cell death called
PANoptosis during infection and inflammation. Sundaram and colleagues recently identified …

In response to infections and tissue damage, ASC-containing inflammasome protein
complexes are assembled that promote caspase-1 activation, IL-1β and IL-18 processing …

Legionella pneumophila is a Gram-negative, flagellated bacterium that survives in
phagocytes and causes Legionnaires' disease. Upon infection of mammalian macrophages …