When “hijacked” by compulsive behaviors that affect the reward and stress centers of the
brain, functional changes in the dopamine circuitry occur as the consequence of …

Reward deficiency syndrome (RDS) was first proposed by Kenneth Blum in 1995 to provide
a clinically relevant and predictive term for conditions involving deficits in mesocorticolimbic …

Dysfunction of central dopaminergic neurotransmission has been implicated in the
pathogenesis of schizophrenia as well as drug and alcohol dependence. Different drugs of …

The progression from recreational drug use to drug addiction impacts multiple
neurobiological processes and can be conceptualized as a transition from positive to …

Addiction to drugs and alcohol is a dynamic and multi-faceted disease process in humans,
with devastating health and financial consequences for the individual and society at large …

Type 2 diabetes and major depressive disorder (MDD) are the leading causes of disability
worldwide and have a high comorbidity rate with fatal outcomes. Despite the long …

Recently there has been debate concerning the role of brain dopamine in reward and
addiction. David Nutt and associates eloquently proposed that dopamine (DA) may be …

Objective: The purpose of this article is to review some of the basic aspects of the
dopaminergic system and its role in reward and pleasure behaviour. We also discuss the …

© Annals of Translational Medicine. All rights reserved. Ann Transl Med 2022; 10 (23): 1291|
https://dx. doi. org/10.21037/atm-2022-67 poor compliance even with the extended-release …

Midbrain dopamine neurons fire irregularly, with interspersed clusters of high-frequency
spikes, commonly called 'bursts'. In this review we examine such heterogeneity in activity …