In presenting a unifying concept for chronic inflammation and lymphoid organogenesis, we
suggest that lymphotoxin's (LT, LT-alpha, TNF-beta) crucial role in these processes is pivotal …

Lymphoid organ development and inflammation have previously been considered as
distinct mechanistically and functionally. In recent years, it has been realized that these …

Targeted mutagenesis in embryonic stem cells was used to generate mice deficient in
lymphotoxin-alpha (LT-alpha). Mice lacking LT-alpha-/-(LT-alpha-/-mice) exhibit a …

Preparations of human lymphotoxins (LT) were effectively cytotoxic to HeLa cells when
applied in the presence of cycloheximide (CHI). In the absence of CHI, however, they failed …

The release of lymphotoxin by PHA-activated normal human lymphocytes in vitro has the
following characteristics: release begins within 2 to 3 hr after derepression, long before any …

LT was one of the first lymphokines to be described and has been one of the most difficult to
fit into a conceptual framework. Now, 20 years after its discovery, its structure, genetic …

Abstract Lymphotoxin-α (LTα), lymphotoxin-β (LTβ), and tumor necrosis factor-α (TNFα) are
inflammatory mediators that play crucial roles in lymphoid organ development. We …

Specialized roles for the pro‐inflammatory cytokines tumor necrosis factor (TNF) and
lymphotoxin (LT) were characterized in TNF/LTα−/− and TNF−/− mice established by direct …

The tumor necrosis factor (TNF) family cytokines lymphotoxin (LT) α and LTβ form
heterotrimers that are expressed on the surface of activated lymphocytes and natural killer …

For more than a decade, the biological roles and the apparent redundancy of the cytokines
tumor necrosis factor (TNF) and lymphotoxin (LT) have been debated. LT alpha exists in its …