The biology of proteostasis in aging and disease
J Labbadia, RI Morimoto - Annual review of biochemistry, 2015 - annualreviews.org
Loss of protein homeostasis (proteostasis) is a common feature of aging and disease that is
characterized by the appearance of nonnative protein aggregates in various tissues. Protein …
characterized by the appearance of nonnative protein aggregates in various tissues. Protein …
Functional modules of the proteostasis network
Cells invest in an extensive network of factors to maintain protein homeostasis (proteostasis)
and prevent the accumulation of potentially toxic protein aggregates. This proteostasis …
and prevent the accumulation of potentially toxic protein aggregates. This proteostasis …
Shaping proteostasis at the cellular, tissue, and organismal level
The proteostasis network (PN) regulates protein synthesis, folding, transport, and
degradation to maintain proteome integrity and limit the accumulation of protein aggregates …
degradation to maintain proteome integrity and limit the accumulation of protein aggregates …
Cell-nonautonomous regulation of proteostasis in aging and disease
RI Morimoto - Cold Spring Harbor perspectives in biology, 2020 - cshperspectives.cshlp.org
The functional health of the proteome is determined by properties of the proteostasis
network (PN) that regulates protein synthesis, folding, macromolecular assembly …
network (PN) that regulates protein synthesis, folding, macromolecular assembly …
Proteostasis impairment in protein-misfolding and-aggregation diseases
Cells possess an extensive network of components to safeguard proteome integrity and
maintain protein homeostasis (proteostasis). When this proteostasis network (PN) declines …
maintain protein homeostasis (proteostasis). When this proteostasis network (PN) declines …
The proteostasis network and its decline in ageing
Ageing is a major risk factor for the development of many diseases, prominently including
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …
Walking the tightrope: proteostasis and neurodegenerative disease
A characteristic of many neurodegenerative diseases, including Alzheimer's disease (AD),
Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis …
Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis …
Pathways of cellular proteostasis in aging and disease
CL Klaips, GG Jayaraj, FU Hartl - Journal of Cell Biology, 2018 - rupress.org
Ensuring cellular protein homeostasis, or proteostasis, requires precise control of protein
synthesis, folding, conformational maintenance, and degradation. A complex and adaptive …
synthesis, folding, conformational maintenance, and degradation. A complex and adaptive …
Systemic stress signalling: understanding the cell non-autonomous control of proteostasis
Proteome maintenance is crucial to cellular health and viability, and is typically thought to be
controlled in a cell-autonomous manner. However, recent evidence indicates that protein …
controlled in a cell-autonomous manner. However, recent evidence indicates that protein …