A major challenge in kidney transplantation (KT) is the large interpatient variability in the
pharmacokinetics of immunosuppressive drugs. Here, we explored the role of the gut …

A major challenge in kidney transplantation (KT) is the large interpatient variability in the
pharmacokinetics of immunosuppressive drugs. Here, we explored the role of the gut …

In this thesis, I provide two examples of precision medicine applications to currently
unsolved drug related problems. In chapter 1, the influence of the microbiome on the …

The human microbiome is associated with human health and disease. Exogenous
compounds, including pharmaceutical products, are also known to be affected by the …

Background The gut microbiome is the full set of microbes living in the gastrointestinal tract
and is emerging as an important dynamic/fluid system that, if altered by environmental …

Tacrolimus dosing to establish therapeutic levels in recipients of organ transplants is a
challenging task because of much interpatient and intrapatient variability in drug absorption …

Despite the recognition, nearly a century ago, that the human microbiome plays a clinically
relevant role in drug disposition, mechanistic insights, and translational applications are still …

The microbiota has important implications for immunosuppressive medications and
immunological outcomes in kidney transplant recipients. Further research is needed to …

Intrinsic metabolism shapes the immune environment associated with immune suppression
and tolerance in settings such as organ transplantation and cancer. However, little is known …

Background: The role of gut microbiome in kidney transplant outcomes has been of great
interest among researchers and physicians. Yet the number of studies to investigate the …